Science
Mechanism of Action
This extract operates by mitigating inflammation through the inhibition of mast cell degranulation, reducing histamine release, and modulating cytokine production, potentially suppressing LPS-induced expression of COX-2 and iNOS mRNA. Its antioxidant capacity is evidenced by its ability to scavenge DPPH and ABTS radicals and decrease intracellular reactive oxygen species. Additionally, it exhibits antimicrobial activity against gram-positive bacteria like *Streptococcus mutans* and fungi such as *Candida albicans*, while also acting as a general skin conditioner.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 In an in vitro study, Streblus Asper Leaf Extract at a concentration of 2 mg/mL exhibited minimum growth inhibitory and bactericidal effects against *Streptococcus mutans*.
- 02 In vitro research showed that 125 mg/mL of the extract achieved 41% inhibition of *Candida albicans* germ tube formation, with inhibition increasing to 61% at a concentration of 250 mg/mL.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract demonstrates stability particularly at alkaline pH levels.
Safety
Safety Profile
No specific safety assessments have been conducted by major regulatory bodies such as CIR, SCCS, or FDA concerning the topical application of Streblus Asper Leaf Extract. While general reviews mention 'some adverse effects' of *Streblus asper* in human trials, these were not specifically attributed to the leaf extract or topical cosmetic use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Streblus Asper Leaf Extract demonstrates compelling *in vitro* antioxidant, anti-inflammatory, and antimicrobial properties; however, the absence of specific human topical safety and efficacy data restricts its confident recommendation for precision skincare formulations at this time.
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References
Sources