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Moumoujus

STIGMASTERYL SUCCINATE.

Valuable CAS 86674-63-7 / EMULSION STABILISING, SKIN CONDITIONING - EMOLLIENT

Stigmasteryl succinate functions as a dual-purpose ingredient, effectively stabilizing emulsions and acting as an emollient to enhance skin feel. While its direct functional roles are well-defined, its close relationship to stigmasterol suggests potential indirect contributions to skin soothing and protection through recognized anti-inflammatory and antioxidant pathways.

Summary

Emulsion Stabilizer Emollient Anti-inflammatory Antioxidant

Science

Mechanism of Action

In formulations, stigmasteryl succinate primarily acts as an emulsion stabilizer, preventing phase separation, and as an emollient, delivering a smooth and conditioned feel to the skin. The active biological effects are largely attributed to its parent compound, stigmasterol. Stigmasterol demonstrates anti-inflammatory properties, potentially mediated by glucocorticoid receptors, which can decrease leukocyte infiltration and reduce edema. It is also shown to reduce levels of inflammatory mediators like TNFα. Furthermore, stigmasterol exhibits antioxidant capabilities and plays a role in maintaining the structural and physiological integrity of cell membranes.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Research on the parent compound, stigmasterol, in rodent models indicates its capacity to mitigate cutaneous allergic responses. Stigmasterol significantly inhibited active cutaneous anaphylaxis, reduced C48/80-induced scratching behavior, and controlled inflammatory features such as ear skin edema and neutrophilia. It also lowered serum levels of TNFα induced by topical TPA.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Stigmasteryl succinate is characterized by high lipophilicity, with a computed XLogP3 of 8.6. The parent compound, stigmasterol, is sparingly soluble in aqueous buffers and insoluble in water, but readily dissolves in organic solvents such as ethanol and DMSO. Aqueous solutions of stigmasterol are not recommended for storage beyond one day.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
8%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded in September 2013 that phytosterols, including stigmasterol, are safe for use in cosmetics at current concentrations and practices. Phytosterols are utilized across a broad range of concentrations, from 0.000001% up to 8% in cosmetic products. While direct specific safety data from SCCS or FDA for Stigmasteryl Succinate was not found, its listing in the EPA CPDat Chemical and Product Categories indicates its presence in consumer products.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Stigmasteryl succinate is a valuable ingredient for its confirmed functional roles as an emulsion stabilizer and emollient, coupled with the promising anti-inflammatory and antioxidant potential demonstrated by its parent compound, stigmasterol.

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References

Sources