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STEWARTIA KOREANA LEAF EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Stewartia Koreana Leaf Extract is a multi-functional botanical extract recognized for its significant capacity to promote skin regeneration and reduce hyperpigmentation. It actively supports cellular proliferation and migration, enhancing the skin's natural repair processes while offering notable antioxidant and anti-inflammatory benefits for a revitalized and brighter complexion.

Summary

Wound Healing Anti-inflammatory Antioxidant Skin Brightening Anti-aging Soothing Cellular Regeneration Angiogenesis Stimulation

Science

Mechanism of Action

Stewartia Koreana Leaf Extract exerts its beneficial effects by stimulating vital cellular processes. It activates key signaling pathways like MAPK, MEK/ERK1/2, and PI3K/Akt, which are crucial for the proliferation and migration of both endothelial cells and skin fibroblasts, thereby promoting wound healing and angiogenesis. Furthermore, it acts as an antioxidant by scavenging free radicals due to its flavonoid and phenolic compound content. The extract also demonstrates anti-inflammatory action by inhibiting NO and PGE2 production, downregulating iNOS and COX-2 expression, and suppressing NF-κB activation. For skin brightening, it inhibits melanogenesis and tyrosinase activity.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Stimulated the proliferation and migration of human umbilical vein endothelial cells without cytotoxicity; promoted angiogenesis and neovascularization in skin punched wounds in vivo.
  2. 02 Increased the proliferation of human dermal fibroblasts by approximately 2.5-fold and 3.7-fold respectively, and enhanced DNA synthesis (BrdU incorporation) by 2.3-fold.
  3. 03 Inhibited melanogenesis in B16F1 cells by approximately 34% without cytotoxicity.
  4. 04 Reduced melanin content by approximately 30% and 57% respectively, without cytotoxicity.
  5. 05 Significantly inhibited tyrosinase and L-DOPA oxidation, showing activity comparable to arbutin, without cytotoxicity.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 6.5 – 6.5
0 7 14

Stability

The extract is soluble in polar solvents like water and methanol, which are frequently used for its extraction. Experimental assays for a related Stewartia extract indicate stability in a potassium phosphate buffer at pH 6.5.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific CIR, SCCS, or FDA safety assessments are currently available for Stewartia Koreana Leaf Extract. However, in vitro studies consistently demonstrate no cytotoxicity at concentrations where biological activity is observed.

Your Skin

Skin Compatibility

Yes Normal
No Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Stewartia Koreana Leaf Extract is a valuable ingredient, demonstrating potent regenerative, anti-inflammatory, and brightening properties crucial for advanced skincare formulations targeting repair and complexion enhancement.

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