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Moumoujus

STEPHANIA CEPHALANTHA ROOT EXTRACT.

Valuable / SKIN CONDITIONING

Stephania Cephalantha Root Extract is a botanical ingredient recognized for its comprehensive skin conditioning benefits, contributing to a softer, smoother, and more hydrated complexion. Its primary active compound, Cepharanthine, offers significant anti-oxidative, anti-inflammatory, and immuno-regulatory properties, enhancing overall skin health and resilience.

Summary

Skin Conditioning Antioxidant Anti-inflammatory Immuno-regulatory Moisturizing Anti-aging Skin Repairing Sebum-Normalizing

Science

Mechanism of Action

The efficacy of Stephania Cephalantha Root Extract is largely attributed to Cepharanthine (CEP). CEP exerts its anti-inflammatory actions by activating AMP-activated protein kinase (AMPK) and inhibiting the NFκB signaling pathways. Furthermore, it actively suppresses critical inflammatory markers such as lipid peroxidation, nitric oxide production, cytokine release, and cyclooxygenase expression, thereby effectively mitigating skin inflammation.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 5.8 – 6.5
0 7 14

Stability

To maintain its integrity and efficacy, the extract should be stored in a cool, dry environment, away from direct sunlight, and kept securely sealed in its original packaging.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Direct safety assessments by CIR, SCCS, or FDA for cosmetic use are currently unavailable. It is important to note that some regions, such as France, prohibit the use of *Stephania cepharantha* extracts due to concerns regarding potential substitution with toxic plants containing aristolochic acids. Conversely, Cepharanthine, the isolated active component, has been safely utilized as an approved pharmaceutical in Japan since the 1950s without significant adverse effects. SkinSAFE categorizes Stephania Cephalantha Root Extract as 'Irritant Free', and INCIdecoder reports low irritancy.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

This extract offers valuable skin conditioning, antioxidant, and anti-inflammatory benefits suitable for all skin types, though formal cosmetic safety reviews and efficacy studies at specific concentrations are currently limited.

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