Science
Mechanism of Action
This extract exerts its dermatological benefits through precise biological pathways. It actively modulates inflammatory responses by inhibiting the production and release of key mediators such as nitric oxide (NO), prostaglandin E2 (PGE2), and interleukin-6 (IL-6) in immune cells. For skin regeneration, it stimulates keratinocyte migration via the β-catenin, extracellular signal-regulated kinase, and Akt signaling pathways, concurrently enhancing the mRNA expression of both type I and III collagen in dermal fibroblasts. Additionally, it functions as a robust antioxidant, effectively scavenging free radicals. In the context of atopic dermatitis, the extract is shown to reduce inflammatory cell infiltration, decrease serum IgE and IL-4 levels, minimize transepidermal water loss, and boost skin hydration, thereby supporting overall skin barrier integrity.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Stellera Chamaejasme is recognized as a toxic plant, with its roots specifically noted for toxic properties upon ingestion (e.g., ethanol root extract LD50: 2080 mg/kg·bw). While no formal cosmetic safety assessments from CIR, SCCS, or FDA are available for the leaf/stem extract in topical use, one source indicates a likelihood of skin irritation and potential for inflammation or dryness when applied topically, suggesting caution.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Stellera Chamaejasme Leaf/Stem Extract demonstrates promising in vitro and animal model data for anti-inflammatory, antioxidant, wound healing, and skin barrier benefits, yet its use is questionable due to noted toxicity concerns and reported potential for skin irritation in the absence of comprehensive human topical safety assessments.
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References
Sources