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STEARYL NICOTINATE RIBOSIDE CHLORIDE.

Valuable / ANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

STEARYL NICOTINATE RIBOSIDE CHLORIDE is an advanced derivative designed to bolster overall skin health. It functions as a precursor to vital cellular coenzymes, supporting crucial repair mechanisms and energy metabolism to foster a resilient skin barrier and diminish visible signs of aging.

Summary

Antioxidant Skin-protecting Anti-aging Cellular repair Barrier enhancement Hydration support

Science

Mechanism of Action

This ingredient serves as a precursor to Nicotinamide Adenine Dinucleotide (NAD+), an essential coenzyme for cellular energy production and optimal skin vitality. Upon topical application, it is believed to metabolize into nicotinamide mononucleotide (NMN) and subsequently NAD+ within the skin's cellular matrix. This biochemical activity drives cellular repair processes, aiding in the reduction of fine lines and wrinkles. Furthermore, it fortifies the skin's barrier function, enhances hydration, improves resilience, and provides antioxidant protection against oxidative stress and environmental aggressors, including UV-mediated damage.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–2%
Optimal

N/A

Key findings

  1. 01 Typical cosmetic formulations utilize concentrations from approximately 0.5% for daily use in moisturizers or serums, increasing up to 2% for intensive anti-aging treatments or specialized serums to improve skin cell function and reduce visible signs of aging.
  2. 02 Treatment with Nicotinamide Riboside is anticipated to counteract UV-mediated degradation of the skin barrier function, specifically by preventing increases in transepidermal water loss (TEWL) and mitigating oxidative damage in human skin cells.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH ≤7
0 7 14

Stability

STEARYL NICOTINATE RIBOSIDE CHLORIDE, a water-soluble crystalline powder, exhibits enhanced stability in acidic to neutral pH environments, with degradation accelerating notably above pH 7.0. It is susceptible to thermal degradation above 130°C and base-catalyzed hydrolysis. Aqueous solutions are not recommended for extended storage beyond one day, necessitating thorough stability testing to ensure ingredient activity in final cosmetic products.

Conflicts

  • High pH environments (above 7.0)
  • Temperatures exceeding 130°C
  • Strong basic conditions

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The specific ingredient, STEARYL NICOTINATE RIBOSIDE CHLORIDE, lacks dedicated safety assessments from the CIR or SCCS in public databases. Safety information primarily pertains to Nicotinamide Riboside Chloride (NRCl), which has received 'Generally Recognized As Safe' (GRAS) status from the FDA for specific food products and dietary supplements. The EFSA (EU) has authorized NRCl as a novel food, permitting up to 300 mg/day for healthy adults and 230 mg/day for pregnant/lactating women in food supplements. While these provide context for a related compound, specific topical safety data for STEARYL NICOTINATE RIBOSIDE CHLORIDE, especially concerning pregnancy, is not readily available.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

STEARYL NICOTINATE RIBOSIDE CHLORIDE is a valuable ingredient that actively supports cellular energy and repair, fortifying the skin's barrier and offering robust protection against environmental stressors for a visibly revitalized and resilient complexion.

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