Science
Mechanism of Action
Stearyl Glycyrrhetinate modulates inflammatory pathways by inhibiting key enzymes, such as phospholipase A₂, and reducing the production of pro-inflammatory cytokines, including TNF‑α and IL‑6, thereby effectively diminishing redness and swelling. It also functions as an antioxidant, neutralizing free radicals and safeguarding skin cells from oxidative stress. This ingredient soothes irritated and sensitive skin, supports the skin's barrier function by mitigating inflammatory damage, aids in moisture retention, and exhibits antibacterial properties. Additionally, it contributes to a skin conditioning effect by forming a protective film that enhances skin smoothness and softness, and can inhibit melanin formation for a skin brightening benefit.
Research
Clinical Evidence
High confidence0.1%
Key findings
- 01 Clinical evaluations consistently demonstrate improvements in redness and irritation in individuals using formulations containing glycyrrhetinic acid derivatives, indicating efficacy in reducing symptoms associated with inflammatory skin conditions.
- 02 Usage concentrations between 0.1% and 1.0% are commonly employed for its anti-inflammatory, soothing, and antioxidant benefits.
- 03 Typical usage levels range from 0.1% to 0.5% for its soothing, antibacterial, and skin-conditioning properties, proving effective in diminishing skin inflammation and irritation, particularly after sun exposure.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient maintains optimal stability within a pH range of 3 to 7. While it is heat tolerant, temperatures exceeding 80°C should be meticulously avoided. It can be melted at room temperature, however, heating to 40-50°C significantly accelerates and facilitates its dissolution in oil. Its stearyl ester structure specifically enhances oil solubility and overall skin compatibility.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Stearyl Glycyrrhetinate is safe under current conditions of use and concentration, specifically up to a maximum of 1% in cosmetic formulations. The CIR recommends adherence to restrictions on impurities. This ingredient is not considered an irritant, sensitizer, phototoxic agent, or photosensitizer at standard maximum use concentrations. Adverse effects are rare, though comprehensive patch testing is advised prior to widespread application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Stearyl Glycyrrhetinate is a valuable ingredient for comprehensive skin care, effectively targeting inflammation and redness while providing antioxidant protection and enhancing overall skin health and comfort across all skin types.
Related
Similar Ingredients
Finding similar ingredients…