Science
Mechanism of Action
Stauntonia Hexaphylla Extract primarily functions by modulating the Akt/NF-κB signaling pathway, which suppresses inflammation by inhibiting the production of LPS-induced nitric oxide (NO) and proinflammatory cytokines. It also demonstrates antioxidant capabilities. In the context of hair health, it acts as a 5α-reductase inhibitor, influencing androgen signaling to mitigate paracrine factors like TGF-β1 and DKK-1 that impact keratinocyte proliferation, thereby preventing premature apoptosis and catagen in hair follicles.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract is noted for its favorable stability in cosmetic formulations, adept at circumventing common stability challenges often associated with other anti-inflammatory agents during cosmetic mixing.
Safety
Safety Profile
In vitro studies confirm a lack of cytotoxicity, with no significant changes in cell viability observed at concentrations up to 200 µg/mL. It has been broadly characterized as safe for use in managing inflammatory conditions.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Stauntonia Hexaphylla Extract is a valuable ingredient, offering well-supported anti-inflammatory and antioxidant benefits, particularly suitable for sensitive skin, and shows promising efficacy in addressing androgenic alopecia.
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References
Sources