Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

SR-STAPHYLOCOCCUS SIMULANS POLYPEPTIDE-1.

Insufficient Data / NOT REPORTED

This innovative peptide, derived from the commensal bacterium *Staphylococcus simulans*, precisely targets and disrupts the quorum sensing system of pathogenic *Staphylococcus aureus*, including MRSA. By inhibiting bacterial communication, it aims to protect the skin from damage, fostering a balanced microbiome and supporting overall skin health.

Summary

Skin Conditioning Microbiome Balancing Barrier Support

Science

Mechanism of Action

SR-STAPHYLOCOCCUS SIMULANS POLYPEPTIDE-1, specifically a class of Autoinducing Peptides (AIPs), functions by interfering with the accessory gene regulator (agr) quorum sensing system of methicillin-resistant *Staphylococcus aureus* (MRSA). This targeted inhibition prevents *S. aureus* from coordinating virulence factor expression, thereby protecting host skin from associated damage, promoting healthy skin homeostasis, and reducing dermonecrotic and epicutaneous skin injury. As a polypeptide, it also provides general skin conditioning benefits.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies demonstrated that synthetic *S. simulans* AIPs inhibited MRSA agr signaling with nanomolar potency.
  2. 02 Murine models showed that intradermally injected *S. simulans* AIP, at doses of 10 μg or 50 μg in neat DMSO, effectively reduced MRSA-induced dermonecrotic and epicutaneous skin injury.

Transparency

Dusting Analysis

Not commonly dusted

Information regarding the common practice of 'dusting' this specific ingredient in cosmetic formulations is not available in the provided research data.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Specific optimal pH ranges or detailed stability data for SR-STAPHYLOCOCCUS SIMULANS POLYPEPTIDE-1 were not identified. General peptide stability can be variable, with some antimicrobial peptides demonstrating optimal stability around pH 3.0. Other anti-virulence compounds have shown chemical stability across a broad range of pH 2-10.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments from regulatory bodies such as CIR, SCCS, or FDA were found for SR-STAPHYLOCOCCUS SIMULANS POLYPEPTIDE-1. Paula's Choice currently lists this ingredient as 'Not rated,' indicating it is under ongoing review, which suggests a lack of comprehensive publicly available safety data at this time.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

SR-STAPHYLOCOCCUS SIMULANS POLYPEPTIDE-1 demonstrates a precise mechanism by inhibiting pathogenic *Staphylococcus aureus* quorum sensing, showing promise for microbiome balance and skin protection in early studies, though comprehensive topical efficacy and safety data for cosmetic use are still emerging.

Related

Similar Ingredients

Finding similar ingredients…