Science
Mechanism of Action
Utilizing a single-chain recombinant polypeptide structure, SR-SPIDER OLIGOPEPTIDE-1 mimics a segment of spider silk protein, produced through fermentation. Its primary action involves creating a breathable, protective film, effectively shielding the skin and hair from environmental aggressors such as pollution, UV radiation, and blue light. Beyond its protective capabilities, it acts as an emollient, offering a superior sensory experience compared to conventional silicones. As a peptide, it actively supports epidermal cell growth, proliferation, and differentiation, contributing to tissue repair and regeneration. This multifaceted mechanism further extends to stimulating collagen synthesis, fortifying the skin's natural barrier function, minimizing the appearance of fine lines and wrinkles, refining skin tone, harmonizing texture, and mitigating irregular pigmentation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Clinical observations indicate that applications containing sr-(Wasp Spider Polypeptide-1 Oligopeptide-178) contribute to a healthier skin appearance, provide a notably silky-soft texture, and offer an immediate firming sensation. Furthermore, it functions as an effective protective film, safeguarding skin and hair from environmental damage, including pollution, UV radiation, and blue light, with sustained protection without accumulation.
- 02 In hair care applications, sr-(Wasp Spider Polypeptide-1 Oligopeptide-178) aids in hair styling, improves curl retention, and promotes a healthier overall appearance.
- 03 For SH-Oligopeptide-1 (Epidermal Growth Factor, EGF), a related peptide, a 2012 study on a serum containing bioengineered epidermal growth factor demonstrated statistically significant improvements in the appearance of fine lines and rhytids, skin texture, pore size, and various dyschromatic conditions within the first month of use, with continued improvement observed over a three-month study duration.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient is water-soluble and stable within an optimal pH range of 5.0 to 8.0. For optimal stability, precise pH adjustment of the product base is crucial before incorporating the diluted peptide solution. Given its sensitivity to enzymatic decomposition by microorganisms, strict aseptic processing is paramount to prevent microbial contamination during manufacturing. It is generally characterized as a stable and potent biotechnological peptide.
Safety
Safety Profile
While no dedicated Cosmetic Ingredient Review (CIR) assessment or SCCS opinion is available for SR-SPIDER POLYPEPTIDE-1 OLIGOPEPTIDE-178 or its direct variants, related sh-oligopeptide-1 (EGF) is authorized for cosmetic use in various concentrations. However, its long-term risks remain unspecified, and its clinical study foundations regarding preclinical bioactivity have been noted to lack scientific rigor. It is important to distinguish that active EGF is considered a potent, unauthorized drug, whereas sh-oligopeptide-1 is permitted as a cosmetic component.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SR-SPIDER OLIGOPEPTIDE-1 is a valuable, multifunctional peptide that offers immediate skin benefits like firming and texture refinement, robust environmental protection, and significant anti-aging potential, making it a compelling addition to advanced skincare and haircare formulations.
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References
Sources