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Moumoujus

SR-SHARK POLYPEPTIDE-1.

Valuable / NOT REPORTED

SR-SHARK POLYPEPTIDE-1, identified also as sh-Polypeptide-1 or bFGF, is a potent cell signaling protein that stimulates dermal fibroblast proliferation. It actively enhances the skin's structural integrity by boosting collagen, elastin, and hyaluronic acid production, contributing to visibly smoother and more elastic skin.

Summary

Cell-Signaling Skin-Conditioning Anti-aging Antioxidant Skin Renewal

Science

Mechanism of Action

This polypeptide functions as a mitogen, primarily by stimulating the growth and proliferation of fibroblasts within the dermal layers of the skin. Its action leads to a significant increase in the synthesis of vital structural proteins, collagen and elastin, thereby enhancing skin elasticity and diminishing the appearance of wrinkles. Furthermore, it boosts hyaluronic acid production, promoting skin hydration and a smoother texture. At a molecular level, it also influences blood vessel development and regulates the intricate processes of epidermal cell propagation, migration, and differentiation.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 5
0 7 14

Stability

As a relatively large polypeptide, its stability and skin penetration are enhanced through advanced delivery systems such as liposomes or PLGA-coated nanoparticles. Optimal stability, particularly to prevent deamidation, is achieved within a pH range of 3.0 to 5.0. Specific amino acids like aspartic acid and asparagine are prone to isomerization and deamination, respectively, while methionine is susceptible to oxidation. The presence of trace metals can also contribute to the formation of high-molecular-weight protein aggregates.

Conflicts

  • strong oxidizing agents
  • pH values between 5 and 8 (promoting deamidation)
  • conditions that promote aspartate isomerization
  • trace metals

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Topical administration studies of sh-Polypeptide-1 have indicated no significant irritation, general toxicity, or adverse effects. However, due to its bFGF-mimetic properties, and the association of bFGF with melanoma progression, caution is advised in its cosmetic application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

SR-SHARK POLYPEPTIDE-1 is a valuable cell-signaling polypeptide that significantly promotes skin regeneration, elasticity, and hydration through increased collagen, elastin, and hyaluronic acid production, though its use warrants caution due to its bFGF-mimetic properties and an unreviewed CIR status.

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