Science
Mechanism of Action
SR-Rainbow Trout Oligopeptide-1 promotes skin regeneration by stimulating epidermal cell proliferation, accelerating skin renewal and repair, and enhancing the synthesis of collagen and elastin. This action aims to improve the skin barrier, suppress inflammatory reactions, and reduce the appearance of cutaneous scars. SH-Polypeptide-9, a cell signaling protein, primarily induces angiogenesis—the formation of new blood vessels. This mechanism facilitates enhanced nutrient and oxygen delivery to skin cells, supports fibroblast activity, promotes overall cellular growth and migration, and aids in wound healing, contributing to smoother, firmer skin and optimized skin vitality.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 A hair booster product containing this ingredient was intended for hair growth, skin protection, and acne. However, this specific product has not been deemed safe or effective by the FDA, and its labeling for these stated uses is not approved.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The 'sh-' prefix indicates that this peptide is a synthetic human version, produced via bioengineering, ensuring high purity, consistency, and ethical sourcing.
Safety
Safety Profile
A product containing 'sr-rainbow trout oligopeptide-1 sh-polypeptide-9' is classified by DailyMed as an 'unapproved drug other,' meaning its labeling lacks FDA approval for safety and effectiveness for its stated uses. While topical application of growth factors is generally considered safe due to limited deep penetration, theoretical concerns regarding their potential to stimulate unwanted cell proliferation (e.g., cancer) have been raised. Long-term risks for sh-oligopeptide-1 as a cosmetic ingredient are currently unknown. For SH-Polypeptide-9 specifically, EWG Skin Deep rates its hazard 'LOW' for Allergies, Immunotoxicity, and Developmental and Reproductive Toxicity, but notes its cancer risk as 'unknown/unassessed' due to insufficient weight of evidence.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While the mechanistic pathways of this combined growth factor and signaling protein suggest promising regenerative and anti-aging benefits, direct clinical efficacy data specifically for the ingredient are limited and FDA approval for efficacy in products containing it is absent, warranting further comprehensive safety and effectiveness research.
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