Science
Mechanism of Action
SR-Rainbow Trout Oligopeptide-1 functions as a Fibroblast Growth Factor (FGF) mimetic, stimulating cellular processes crucial for skin regeneration and healing. It promotes the synthesis of collagen and elastin, foundational proteins for maintaining skin structure and elasticity. SH-Polypeptide-8 is engineered as a synthetic human peptide that mirrors Platelet-Derived Growth Factor (PDGF), broadly contributing to cell proliferation, tissue repair, and wound healing within the skin matrix.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 A product containing this ingredient was investigated for external application for hair growth, skin protection, and acne, utilizing a concentration of 0.0001%. However, the FDA has not affirmed the safety or efficacy of this product, nor has its labeling received FDA approval.
Transparency
Dusting Analysis
This ingredient's specific nature and significant regulatory scrutiny suggest it is not commonly used merely for label appeal without functional intent. However, its unapproved status raises questions about its appropriate inclusion in cosmetic formulations.
The Formula
Formulation
Stability
Optimal storage conditions are between 2-25°C (36-77°F), with strict avoidance of freezing and temperatures exceeding 40°C (104°F). For related larger peptide molecules, advanced delivery systems such as liposomes or PLGA-coated nanoparticles may be employed to enhance stability, improve skin penetration, and optimize therapeutic efficiency. Broader rainbow trout hydrolysates exhibit highest solubility at pH 8, with reduced solubility below pH 6.
Safety
Safety Profile
Products incorporating this ingredient have been designated by the FDA via DailyMed as 'unapproved drug other,' explicitly stating that the FDA has not determined them to be safe or effective, and their labeling is unapproved. For related ingredients like sh-Oligopeptide-1 (EGF), while authorized as a cosmetic in varying concentrations, long-term risks remain unknown. Concerns have also been raised regarding the scientific rigor and use of inactive ingredients in some clinical studies involving sh-Oligopeptide-1.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While mechanistically designed to support skin regeneration and elasticity, the FDA's classification of products containing this ingredient as 'unapproved drug other' and its explicit lack of safety and efficacy approval raise substantial concerns for cosmetic formulation.
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References
Sources