Science
Mechanism of Action
The primary mechanism of action relies on its growth factor components. SH-Oligopeptide-1, also known as Epidermal Growth Factor (EGF), binds to specific receptors on keratinocytes to stimulate cell proliferation, differentiation, and tissue repair. This action aids in skin regeneration, helps reduce the appearance of wrinkles, improves skin tone, and stimulates the production of collagen and elastin, contributing to scarless wound healing and addressing pigmentation irregularities. SH-Polypeptide-1, an analog of basic Fibroblast Growth Factor (bFGF or FGF2), further promotes skin renewal, increases collagen and elastin synthesis for improved skin elasticity and smoother texture, and drives new blood vessel formation. It can also synergistically interact with EGF and IGF-1 to boost hyaluronic acid production. SR-Rainbow Trout Oligopeptide-1, a recombinant protein derived from rainbow trout protamine-2, likely contributes to skin conditioning or ingredient stabilization within the formulation.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 A concentration of 0.0001% was identified in an unapproved hair booster product, but the FDA explicitly states that the ingredient's safety and effectiveness for this use, and its labeling, are not approved. Therefore, efficacy at this concentration is not clinically proven.
- 02 For the component sh-Oligopeptide-1 (EGF), reported benefits include enhanced wound healing, support for skin regeneration, increased skin moisture and elasticity, decreased transepidermal water loss (TEWL), reduction in melasma, and decreased inflammatory acne lesions. However, specific concentrations for these benefits regarding the combined 'SR-RAINBOW TROUT OLIGOPEPTIDE-1 SH-POLYPEPTIDE-1' are not provided.
- 03 Clinical studies for sh-oligopeptide-1 (EGF), a key component, are deemed to lack scientific basis due to unproven preclinical bioactivity, raising questions about fundamental efficacy claims.
Transparency
Dusting Analysis
Insufficient data available to determine common dusting practices or specific thresholds for this ingredient.
The Formula
Formulation
Stability
SH-Polypeptide-1 is a relatively large molecule, and its stability, penetration, and efficiency in topical applications are often enhanced by packaging it within advanced delivery systems, such as liposomes or PLGA-coated nanoparticles. Peptides, in general, are recognized for their water solubility.
Synergies
- SH-Polypeptide-1 can interact with EGF and IGF-1 to boost hyaluronic acid production, suggesting synergistic potential within a multi-peptide formulation.
Safety
Safety Profile
The FDA has issued a disclaimer indicating that products containing 'SR-RAINBOW TROUT OLIGOPEPTIDE-1 SH-POLYPEPTIDE-1' have not been found safe and effective, and their labeling has not received drug approval. While its component, sh-Oligopeptide-1 (EGF), is authorized for general cosmetic use in various concentrations, potential long-term risks remain undefined. There are no direct safety assessments available from the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS) specifically for the combined ingredient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite its theoretical promise for skin regeneration and anti-aging benefits due to its growth factor components, the ingredient's safety and efficacy are explicitly unapproved by the FDA, with limited and conflicting clinical validation for the combined form.
Related
Similar Ingredients
Finding similar ingredients…