Science
Mechanism of Action
This oligopeptide functions by binding to the epidermal growth factor receptor (EGFR) on skin cells, initiating a sophisticated signaling cascade that regulates cell survival, differentiation, and proliferation. It directly stimulates the growth and division of skin cells, enhancing the integrity and resilience of the skin barrier. The ingredient significantly boosts collagen and elastin production for improved firmness and elasticity, alongside increasing hyaluronic acid synthesis for optimal hydration. Furthermore, it stimulates keratinocyte proliferation and migration, promotes fibroblast viability, and accelerates wound healing processes by enhancing blood vessel formation and releasing rejuvenating growth factors, which contributes to scarless healing. It also exhibits anti-inflammatory properties and reinforces the production of vital extracellular matrix components.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Clinical evaluations using Oligopeptide-1 at concentrations from 0.01% to 0.5% have shown a significant increase in skin elastin and type I collagen precursor content, resulting in visible wrinkle reduction.
- 02 A 2012 study on a serum incorporating barley bioengineered SH-Oligopeptide-1 demonstrated statistically significant improvements in the appearance of fine lines, rhytids, skin texture, pore size, and various dyschromatic conditions within the initial month, with ongoing enhancement over three months.
- 03 An EGF cream containing SH-Oligopeptide-1 was observed to reduce inflammatory acne lesions by 33.5% over a six-week period in a study involving 20 subjects.
- 04 Evidence suggests efficacy in promoting wound healing for diabetic patients post-laser treatment and in the management of Senile purpura.
- 05 At a concentration as low as 0.0001%, this ingredient has been incorporated into hair booster products for its potential in hair growth, skin protection, and acne management.
Transparency
Dusting Analysis
No specific data regarding dusting practices for this ingredient were found in the provided research.
The Formula
Formulation
Stability
Due to its considerable molecular size, SH-Oligopeptide-1 may present challenges in skin penetration. Products containing similar 'sr-rainbow trout oligopeptide' variants require specific storage conditions, optimally between 2-25℃ (36-77℉), with strict avoidance of freezing and exposure to excessive heat above 40℃ (104℉), indicating temperature sensitivity.
Safety
Safety Profile
The FDA has not deemed products containing 'sr-rainbow trout oligopeptide-1 sh-polypeptide-13' (or similar variants) safe and effective as a drug, and their labeling has not received FDA approval. As SH-Oligopeptide-1 (EGF) is a growth factor, its overexpression or dysregulation carries a potential risk for tumorigenesis, given that EGF signaling is active in many tumor cells. Therefore, its application in personal care formulations warrants caution. While some evidence suggests a potential to promote the growth of existing cancerous tumors, this finding remains inconclusive. Furthermore, certain clinical studies on SH-Oligopeptide-1 may lack a strong scientific foundation, with preclinical bioactivity often unproven, and it is authorized as a cosmetic at various concentrations with currently unknown long-term risks. Generally considered non-irritating, the risk of irritation may increase when combined with problematic ingredients. Paula's Choice indicates an ongoing review, without a definitive rating as of current research.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While demonstrating significant potential for skin regeneration, anti-aging, and restorative benefits, its classification as a growth factor raises legitimate safety concerns regarding potential tumorigenesis and the absence of comprehensive long-term safety data, necessitating cautious consideration for formulation.
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