Science
Mechanism of Action
This sophisticated peptide operates by signaling the skin to activate its endogenous repair pathways, contributing to improved structural integrity and a reduction in visible wrinkles through the stimulation of regenerative processes for proteins such as collagen. Concurrently, autoinducing peptides (AIPs) originating from the Staphylococcus simulans component precisely inhibit the quorum sensing of pathogenic bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), thereby protecting the host skin from damage. Furthermore, the Staphylococcus phage 2638A polypeptide, derived from a phage endolysin, demonstrates lytic activity against Staphylococcus aureus, suggesting a targeted antimicrobial function that aids in maintaining a balanced skin microbiome.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies have demonstrated that synthetic Staphylococcus simulans autoinducing peptides (AIPs), components related to this ingredient, effectively inhibited MRSA agr signaling at nanomolar concentrations.
- 02 Research in murine models indicated that synthetic Staphylococcus simulans AIP-I, a relevant component, significantly reduced dermonecrotic and epicutaneous skin injury.
- 03 The Staphylococcal phage 2638A endolysin component exhibits lytic activity against Staphylococcus aureus upon external exposure, suggesting its potential as an antimicrobial agent.
Transparency
Dusting Analysis
As a novel and complex polypeptide, there is no available data to suggest it is commonly 'dusted' or used at ineffective percentages in cosmetic formulations.
The Formula
Formulation
Stability
This ingredient generally maintains viability between 4°C and 50°C. However, it is sensitive to elevated temperatures, experiencing rapid inactivation at or above 70°C. While its overall viability spans a pH range of 4.0 to 11.0, the optimal stability for its bacteriophage-derived component is observed between pH 6.0 and 8.0, with rapid inactivation occurring in highly acidic environments (pH ≤ 3.0).
Conflicts
- High heat (≥ 70°C)
- Extreme acidic environments (pH ≤ 3.0)
Safety
Safety Profile
This ingredient has not been directly reviewed by CIR, SCCS, or FDA. However, assessments by SkinSAFE classify it as 'Teen SAFE', 'Irritant Free', 'Fragrance Free', and 'Common Preservative Free', indicating a favorable safety profile and a low potential for irritation, particularly for individuals with sensitive skin.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This innovative ingredient offers significant value through its multifaceted approach to skin health, combining anti-aging benefits with precise microbiome modulation and robust skin conditioning properties.
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References
Sources