Science
Mechanism of Action
SR-(METHIONYL SH-POLYPEPTIDE-38 DIPEPTIDE-19 HEXAPEPTIDE-40) functions primarily as a sophisticated signaling molecule. Its structure is designed to engage the skin's intrinsic repair pathways, specifically targeting the stimulation of collagen biosynthesis. This activity is expected to yield improvements in skin elasticity, firmness, and hydration, concurrently diminishing the appearance of fine lines and wrinkles through fortified dermal architecture. Furthermore, this class of peptides is recognized for its capacity to condition the skin, reinforce the natural barrier, optimize moisture retention, and offer protection against environmental stressors.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 No direct clinical studies with reported concentrations are available for SR-(METHIONYL SH-POLYPEPTIDE-38 DIPEPTIDE-19 HEXAPEPTIDE-40). However, in-vitro investigations on similar recombinant collagen peptides indicate efficacy within the 0.05% to 0.2% range for promoting collagen concentration, supporting skin repair, exhibiting anti-wrinkle properties, and providing soothing benefits. Broader peptide research suggests other types, like Polypeptide 69, are utilized at concentrations between 2.5% and 10% for stimulating collagen synthesis and inhibiting collagenase activity.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While specific data for this exact INCI is limited, related recombinant collagen products are noted for their neutral pH compatibility, suggesting good stability within formulations around a neutral pH range.
Safety
Safety Profile
Direct safety assessments by regulatory bodies such as CIR, SCCS, or FDA for this specific ingredient are currently unavailable. Analogous recombinant peptides, including Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47, are generally considered safe for topical application. However, as with many active ingredients, potential mild adverse reactions such as transient skin irritation, redness, or localized allergic responses cannot be entirely excluded. Manufacturers producing related recombinant collagens often assert their products are non-allergenic and exhibit reduced immunogenicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While the observed in-vitro potential for collagen synthesis and skin revitalization in analogous recombinant peptides is promising, the absence of specific clinical studies and comprehensive safety evaluations for SR-(METHIONYL SH-POLYPEPTIDE-38 DIPEPTIDE-19 HEXAPEPTIDE-40) currently limits a definitive assessment of its precise efficacy and safety profile.
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