Science
Mechanism of Action
SR-(METHIONYL OLIGOPEPTIDE-91 GLUTAMINYL CLOSTRIDIUM BOTULINUM POLYPEPTIDE-1 HEXAPEPTIDE-40) is a single-chain recombinant peptide, approximately 433 to 469 amino acids in length, produced via E. coli fermentation. It integrates a 'Macro-molecule Transmission Domain' (MTD), derived from the heavy chain of botulinum toxin, which facilitates its permeation into skin and nerve cells. This MTD technology efficiently delivers the active 'Botulinum Efficacy Part' (Light Chain) into target cells, thereby mimicking the effects of botulinum toxin topically to reduce wrinkles and enhance skin elasticity. Beyond this targeted action, the peptide also acts as a signaling molecule, activating the skin's natural repair mechanisms, and forms a protective barrier to condition the skin and shield it from environmental stressors.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 This ingredient demonstrably improves various skin parameters including wrinkle reduction, increased skin elasticity, and a decrease in enlarged pore appearance. It also contributes to an overall improvement in skin flush and provides a strong lifting effect, particularly on skin with reduced elasticity. Its effects are likened to dermotoxin injections, with a reported faster manifestation time than traditional medical botox muscle injections, and a comparable duration to dermotoxin.
- 02 It aids in forming a protective barrier against environmental aggressors such as pollution, UV radiation, and harsh weather, preventing damage and mitigating premature aging.
- 03 The ingredient provides conditioning benefits, leading to enhanced skin texture, smoothness, evenness, and sustained hydration and suppleness.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While specific stability notes are not detailed, products containing similar recombinant peptides are typically liquid formulations designed for room temperature storage.
Safety
Safety Profile
Generally regarded as safe for topical cosmetic application, comprehensive data regarding its use during pregnancy and breastfeeding is currently insufficient; individuals in these categories are advised to seek professional medical consultation. A preliminary patch test is recommended before extensive application to ensure no adverse skin reactions. This specific peptide was officially listed on the International Cosmetics Ingredient Dictionary (ICID) in December 2014.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This advanced recombinant peptide delivers potent anti-aging benefits, including wrinkle reduction and elasticity improvement, alongside significant skin conditioning and environmental protection, making it a valuable addition for precision skincare formulations.
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