Science
Mechanism of Action
This ingredient functions as a cellular signal molecule, specifically binding to epidermal growth factor receptors (EGFR) to stimulate the growth, proliferation, and differentiation of epidermal cells. It directly promotes skin repair, including scarless wound healing, by enhancing blood vessel formation and stimulating the secretion of rejuvenating growth factors. Furthermore, SR-HORSE OLIGOPEPTIDE-1 boosts the production of crucial extracellular matrix components such as collagen, elastin, and glycosaminoglycans (e.g., hyaluronic acid), which collectively contribute to improved skin barrier function, suppressed inflammatory reactions, reduced cutaneous scars, and long-term moisturization. It can also aid in reducing dark spots and may help minimize acne breakouts by reinforcing the epidermal barrier.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A 2012 study observed statistically significant improvements in fine lines, rhytids, skin texture, pore size, and various dyschromatic conditions within the first month of using a serum containing barley bioengineered epidermal growth factor, with sustained benefits over the 3-month study duration.
- 02 Clinical assessments of 'Oligopeptide-1' demonstrated statistically significant enhancements in the appearance of fine lines, skin texture, pore size, and dyschromatic conditions within the initial month of use. It also showed benefits in nourishing, smoothing, lightening, rejuvenating tired skin, and assisting in scar reduction.
- 03 Several clinical trials have reported sh-Oligopeptide-1's effectiveness in promoting wound healing for diabetic patients after laser treatment and in the management of senile purpura.
- 04 Conversely, a critical review concluded that clinical studies on sh-oligopeptide-1 often lack scientific basis, citing unproven preclinical bioactivity and trials potentially not adhering to medical standards.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
SR-HORSE OLIGOPEPTIDE-1 is highly sensitive to pH, requiring formulations to be adjusted to a pH range of 5.0-8.0 before its incorporation. It is also susceptible to enzymatic decomposition by microorganisms, necessitating rigorous microbial contamination control during processing to preserve its activity and efficacy.
Safety
Safety Profile
The safety of SH-Oligopeptide-1 (EGF), which SR-HORSE OLIGOPEPTIDE-1 is presumed to refer to, has not been directly reviewed by CIR or SCCS. The FDA considers active EGF a potent, unauthorized drug, not a cosmetic ingredient, and its topical use outside clinical trials is not authorized. China's National Drug Administration advises against its use as a cosmetic raw material due to its large molecular weight and potential safety issues, particularly when the skin barrier is incomplete. While most experts agree EGF is mitogenic (stimulates cell proliferation) but not mutagenic (does not cause cancer), concerns exist regarding its potential to promote the growth of *existing* cancerous tumors; however, this evidence remains inconclusive. It is generally considered safe for individuals without a history of skin cancer and is not on EWG's Restricted or Unacceptable Lists.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While SR-HORSE OLIGOPEPTIDE-1 (EGF) demonstrates promising efficacy in clinical studies for skin rejuvenation and repair, its classification by the FDA as an unauthorized drug, cautionary advice from China's NDA, and critical reviews questioning the scientific basis of some trials introduce significant concerns regarding its regulatory status and long-term safety in cosmetic applications.
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