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SR-ESCHERICHIA COLI POLYPEPTIDE-1 TRIPEPTIDE-64 SR-SILKWORM POLYPEPTIDE-1 SH-POLYPEPTIDE-50 OLIGOPEPTIDE-144 HEXAPEPTIDE-40.

Valuable / HUMECTANT, SKIN CONDITIONING

This advanced polypeptide complex, bio-engineered from sources including *E. coli* and silkworms, offers a comprehensive approach to skin health. It effectively hydrates and conditions the skin, while simultaneously delivering significant anti-aging benefits and environmental protection.

Humectant Skin Conditioning Film Former Skin Protecting Hair Conditioning Emollient Cell-communicating ingredient

Science

This sophisticated blend exerts its effects through multiple synergistic mechanisms. Broadly, peptides signal the skin to activate its endogenous repair processes, contributing to visible anti-aging improvements. Specifically, recombinant spider silk polypeptides create a protective, breathable film on the skin's surface, shielding it from environmental aggressors such as pollution, UV radiation, and blue light. These components also function as emollients, promoting a soft skin texture and providing an instant firming sensation, concurrently enhancing the skin's natural barrier function. Silkworm polypeptides, primarily sericin, are recognized for their potent moisturizing capabilities, antioxidant potential, support for wound healing, promotion of cell proliferation, and additional protection against ultraviolet radiation. SH-Polypeptide-1, identified as Basic Fibroblast Growth Factor, is critical for stimulating fibroblast cell growth, proliferation, and the synthesis of collagen and other essential extracellular matrix components. Lastly, SH-Polypeptide-50, or Tropoelastin, directly supports and contributes to enhanced skin elasticity.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Components like silkworm sericin and recombinant spider silk proteins are water-soluble, with the latter often provided as hydrophilic powders. While some antimicrobial peptides derived from silkworms may exhibit susceptibility to proteolytic degradation and varying stability with pH and ionic strength, related recombinant silk proteins are noted for broad pH stability and overall robustness, suggesting good stability for the overall blend. No specific formulation incompatibilities have been reported.


Safety

CIR Status
Not reviewed
Sensitization risk Moderate

A direct safety assessment from CIR, SCCS, or FDA is not available for this complete ingredient. While generally considered non-irritating, there is a moderate potential for irritation, a risk that may be heightened when combined with other potentially problematic ingredients. Studies concerning other silk protein ingredients have indicated low acute oral and dermal toxicity.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Valuable

This multi-functional polypeptide blend offers significant benefits for hydration, environmental protection, and anti-aging, making it a valuable addition for comprehensive skin and hair care across all skin types, despite the absence of specific clinical studies on the complete complex.


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