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Moumoujus

SR-DOG POLYPEPTIDE-2.

Questionable / ANTIOXIDANT, HAIR CONDITIONING, SKIN PROTECTING

SR-DOG Polypeptide-2 is a synthetic single-chain polypeptide engineered to mimic the body's natural Insulin-like Growth Factor 1 (IGF-1). It actively supports cellular regeneration, enhances skin elasticity and hydration, and aims to visibly reduce the signs of aging by boosting collagen and elastin production. This ingredient works to revitalize skin cells and foster overall skin health.

Summary

Anti-aging Collagen booster Elasticity enhancer Hydration support Cell regeneration Wound healing Skin barrier support Firming Cell-communicating ingredient

Science

Mechanism of Action

SR-DOG Polypeptide-2 functions as a synthetic analog of Insulin-like Growth Factor 1 (IGF-1), a naturally occurring polypeptide crucial for cell growth and regeneration. It operates by activating the AKT cellular signaling pathway, which is essential for anti-aging processes and promoting the repair of damaged cells. When applied topically, it stimulates fibroblast proliferation, leading to an increased biosynthesis of collagen, elastin, hyaluronic acid, and other critical extracellular matrix components. This action results in enhanced skin elasticity, improved firmness, and superior hydration, visibly minimizing the appearance of fine lines, deep wrinkles, and blotchiness, while also reinforcing the skin barrier and optimizing cellular communication.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Mimicking Insulin-like Growth Factor 1 (IGF-1), SR-DOG Polypeptide-2 is associated with observed reductions in skin wrinkling and an improved perceived age, reflecting its role in skin rejuvenation.
  2. 02 Topical application of SR-DOG Polypeptide-2 has been shown to stimulate fibroblast proliferation and collagen synthesis, leading to enhanced skin elasticity and improved hydration.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Formulating with growth factor-mimicking peptides, including similar types like sh-oligopeptide-1, presents inherent complexities in maintaining stability and bioactivity. Manufacturers have faced difficulties in providing preparations with consistent, stable bioactive forms at well-defined concentrations suitable for rigorous clinical evaluation.

Conflicts

  • Use with caution in formulations due to the potential correlation between growth factors and tumorigenesis or progression; recombinant IGF-1 has specifically been linked to Melanoma progression in some studies.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

While generally recognized as safe for cosmetic applications by regulatory bodies such as the European Cosmetics Directive, individual reactions to SR-DOG Polypeptide-2 should be closely monitored. Serious side effects are infrequently reported, though allergic responses are possible, particularly in individuals with pre-existing dermatological sensitivities. A cautious approach is advised for any growth factor-mimicking peptide, as growth factors have been correlated with tumorigenesis or progression; recombinant IGF-1 has been specifically implicated in Melanoma progression. This ingredient is not listed on EWG's Restricted or Unacceptable Lists.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

SR-DOG Polypeptide-2 demonstrates promising anti-aging and regenerative properties by mimicking IGF-1, but its application warrants extreme caution due to documented concerns regarding growth factor correlation with tumorigenesis and formulation stability challenges.

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