Science
Mechanism of Action
As a fundamental cell signaling protein and mitogen, SR-DOG Polypeptide-1 stimulates cell proliferation. Its primary action involves significantly boosting the growth and multiplication of fibroblasts, key cells responsible for synthesizing critical extracellular matrix components such as collagen and elastin. Concurrently, it enhances Keratinocyte Growth Factor (KGF) expression, which leads to increased keratinocyte proliferation and consequently, a reinforced epidermal barrier. These actions are pivotal for effective wound healing and overall skin regeneration.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) noted that 'sr-Polypeptide-1' (a designation often used for recombinant human peptides like SH-Polypeptide-1) held an 'unknown' safety status as of 2022, though it was proposed for inclusion in their 2023 priorities list for further review. General safety assessments for related tissue-derived proteins and peptides typically conclude they are safe for cosmetic applications as skin and hair conditioning agents. Specific SCCS or FDA status for SH-Polypeptide-1 is not detailed in the provided data.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SR-DOG Polypeptide-1 is a valuable cell-communicating ingredient that significantly supports skin regeneration by boosting collagen and elastin synthesis and strengthening the epidermal barrier.
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References
Sources