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Moumoujus

SPLEEN HYDROLYSATE.

Valuable CAS 91080-06-7 / SKIN CONDITIONING

Spleen Hydrolysate, a rich source of bio-active peptides and amino acids, exhibits significant potential in advanced skincare formulations. Research indicates its capacity to improve skin hydration and reduce visible signs of aging, while providing robust antioxidant protection.

Summary

Antioxidant Hydrating Anti-aging Anti-inflammatory Collagen synthesis stimulator Elastin synthesis stimulator

Science

Mechanism of Action

Operating through robust radical scavenging and hydroperoxide reduction, Spleen Hydrolysate functions as a potent antioxidant both in vitro and in vivo. As a protein hydrolysate, its constituent peptides and amino acids are theorized to contribute to broader anti-aging and anti-inflammatory effects, potentially supporting the synthesis of vital skin proteins like collagen and elastin.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Clinical observations reveal that formulations containing Spleen Hydrolysate, particularly when enriched with bio-active peptide SA1-III, can lead to substantial improvements in skin puffiness, superficial and deep wrinkles, and overall dryness. Notably, skin hydration levels have been shown to increase significantly, ranging from 32.0% in serum to 43.1% in cream applications.
  2. 02 In vitro studies confirm its superior antioxidant capacity, with an effective dose for scavenging 50% of DPPH radicals (EC50) at 1.16 mg/assay, demonstrating a more potent effect compared to casein hydrolysate, with subsequent in vivo antioxidant activity also observed.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The ingredient is water-soluble. Its enzymatic preparation occurs under alkaline conditions (pH 8.0) and moderate heat (55°C), suggesting stability within similar processing environments. Proteins generally exhibit optimal solubility in alkaline conditions, with minimum solubility at their isoelectric point.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While Spleen Hydrolysate itself has not undergone specific safety reviews by major regulatory bodies like CIR, SCCS, or FDA, the CIR Expert Panel has deemed other protein hydrolysates, such as Hydrolyzed Collagen, safe for cosmetic use, reporting no instances of skin sensitivity, phototoxicity, or irritation in clinical contexts. This suggests a potentially low risk profile for Spleen Hydrolysate as a class.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Spleen Hydrolysate offers promising anti-aging and hydrating benefits alongside robust antioxidant protection, making it a valuable active ingredient despite pending specific regulatory review.

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