Science
Mechanism of Action
This extract operates through a multifaceted approach to skin health. It acts as a powerful antioxidant, effectively scavenging free radicals and mitigating oxidative stress. Its anti-inflammatory capabilities are demonstrated by its ability to reduce redness, suppress proinflammatory chemokine production, and inhibit inflammatory mediators such as NO and TNF-α, partly via inhibition of MAPK/STAT1/NF-κB activation. Furthermore, it directly inhibits human neutrophil elastase activity, an enzyme contributing to collagen and elastin degradation. The extract also provides protection against UVB-induced photo-aging by reducing reactive oxygen species generation, preventing cellular damage, and positively influencing the expression of matrix metalloproteinases (MMPs), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), collagen type I alpha 1 (COL1A1), elastin (ELN), and hyaluronan synthase 2 (HAS2). Beyond these, it functions as a skin emollient, promoting a smoother texture and helping to even out skin tone.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Inhibited human neutrophil elastase (HNE) activity (IC50) with a phenolic extract containing 81.4% phenolic contents.
- 02 Aqueous and ethanolic extracts decreased UVB-stimulated reactive oxygen species (ROS) production by approximately 11% and 18%, respectively, in HaCaT cells.
- 03 Showed 79% inhibition of elastase activity.
- 04 Suppressed proinflammatory chemokine production in IFN-γ/TNF-α–stimulated HaCaT cells (in vitro).
- 05 Ameliorated atopic dermatitis–like symptoms, including ear thickness, dermatitis score, and epidermal thickness, in Dermatophagoides farina extract (DfE)–treated NC/Nga mice (in vivo).
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract is chemically stable under standard ambient conditions (room temperature). For optimal stability and shelf-life, it should be stored protected from light and humidity in tightly closed vessels.
Safety
Safety Profile
While formal safety assessments by regulatory bodies such as CIR, SCCS, or FDA are not specified, general safety data sheets indicate this ingredient is considered non-toxic and non-irritating to the skin. Incidecoder also rates its irritancy as low.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Spatholobus Suberectus Stem Extract is a valuable botanical ingredient offering comprehensive antioxidant, anti-inflammatory, and anti-aging benefits, suitable for a wide range of skin types.
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References
Sources