Science
Mechanism of Action
This extract functions by precisely modulating inflammatory pathways within the skin. It actively suppresses the synthesis of proinflammatory chemokines and inhibits the phosphorylation of mitogen-activated protein kinase (MAPK). Additionally, it prevents the activation and nuclear translocation of crucial transcriptional factors, including STAT1 and NF-κB, in stimulated keratinocytes, thereby mitigating the inflammatory cascade at a cellular level.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In preclinical studies, oral administration of Spatholobus suberectus Dunn water extract (SSWex), derived from a 100 mg/ml stock solution, significantly alleviated atopic dermatitis-like symptoms in DfE-treated NC/Nga mice. Observed benefits included reductions in ear thickness, dermatitis scores, epidermal thickness, immune cell infiltration, and levels of AD-related serum parameters such as immunoglobulin E, histamine, and proinflammatory chemokines.
- 02 In vitro investigations utilizing variable dilutions from a 100 mg/ml stock solution demonstrated that SSWex effectively inhibited the production of proinflammatory chemokines in HaCaT keratinocytes, which were induced by inflammatory cytokines such as interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α).
Transparency
Dusting Analysis
Current research data primarily details experimental concentrations (e.g., 100 mg/ml stock solutions for dilutions) used in preclinical studies. These do not provide specific guidelines or evidence of common 'dusting' practices in typical cosmetic product formulations, nor do they define a threshold for such concerns.
The Formula
Formulation
Stability
The extract is described as possessing a slightly acidic pH. However, a precise optimal pH range for its stability and performance within cosmetic formulations has not been specified in the available research.
Safety
Safety Profile
No specific safety assessments for cosmetic application have been conducted or reviewed by major regulatory bodies such as CIR, SCCS, or FDA. While general internal therapeutic use of the herb indicates negligible side effects, this information does not directly translate to topical cosmetic safety.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Spatholobus Suberectus Extract is a valuable ingredient with significant potential for calming and protecting reactive skin, substantiated by its potent anti-inflammatory and antioxidant properties demonstrated in preclinical studies.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources