Science
Mechanism of Action
Sorghum Vulgare Seed/Skin/Stalk Extract functions as a robust anti-inflammatory agent, actively reducing skin inflammation and soothing irritation, thereby lessening neurosensory discomfort. This action is supported by its capacity to suppress pro-inflammatory cytokines such as IL-1β, TNF-α, and IFN-γ. Its abundance of flavonoids and polyphenols confers potent antioxidant properties, effectively combating free radicals and mitigating oxidative stress. The ingredient also significantly contributes to anti-aging and improved skin elasticity by enhancing firmness, visibly reducing fine lines and imperfections, promoting collagen synthesis, and inhibiting photoaging enzymes like elastase, collagenase, and tyrosinase. Additionally, it aids in moisture retention and strengthens the skin barrier through its rich vitamin and mineral content.
Research
Clinical Evidence
Medium confidenceBased on available human clinical data, concentrations between 3% and 10% have demonstrated efficacy.
Key findings
- 01 Pretreatment of sensitive forearm skin with 10% Sorghum Vulgare Seed/Skin/Stalk Extract in water significantly lowered inflammation when subsequently exposed to 0.1% methyl nicotinate, as confirmed by subepidermal imaging.
- 02 Application of 3% Sorghum Vulgare Seed/Skin/Stalk Extract in water to the nasal fold notably reduced neurosensory irritation, with subjects reporting a lower stinging reaction after exposure to 12% lactic acid.
- 03 Enzymatically derived peptides from white sorghum kafirins (<1 kDa and 1-3 kDa fractions) exhibited substantial protective effects on human skin cell cultures exposed to UVB radiation, effectively reducing oxidative stress, suppressing pro-inflammatory cytokines (IL-1β, TNF-α, IFN-γ), and inhibiting enzymes associated with photoaging (elastase, collagenase, tyrosinase).
Transparency
Dusting Analysis
No specific data regarding 'dusting' practices or thresholds for this ingredient is available in the research provided.
The Formula
Formulation
Stability
Key phenolic compounds within sorghum extracts are water-soluble and typically extracted using aqueous or ethanol-water mixtures. While a specific optimal pH range for cosmetic formulation stability is not provided, studies on a similar sorghum bicolor seed extract for tissue staining indicated efficacy within a pH range of 5.5 to 7.0, suggesting potential stability in slightly acidic to neutral environments.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically assessed 'Sorghum Vulgare Seed/Skin/Stalk Extract'. For 'sorghum vulgare seed extract', no GHS hazard statements or precautionary statements were found, and oral, dermal, and inhalation toxicity were reported as 'not determined'. It is recommended for 'not for fragrance use' and 'not for flavor use' in cosmetics. FDA listings for 'sorghum vulgare seed extract' as a food additive are not directly equivalent to cosmetic safety assessments.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Sorghum Vulgare Seed/Skin/Stalk Extract is a valuable botanical ingredient, clinically demonstrated to reduce inflammation and irritation while providing significant antioxidant, anti-aging, and moisturizing benefits across various skin types.
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