Science
Mechanism of Action
This extract operates through a complex array of mechanisms on the skin. It acts as a robust antioxidant, effectively scavenging free radicals and inhibiting lipid peroxidation due to its rich composition of polyphenolic compounds, flavonoids, phenolic acids, and anthocyanins, thereby reducing oxidative stress. Its anti-inflammatory action is demonstrated by the reduction of key pro-inflammatory cytokines such as interleukin-1β (IL-1β), interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α), alongside diminishing myeloperoxidase activity. For anti-aging, it improves skin elasticity, reduces the appearance of fine lines, and inhibits collagenase, elastase, and tyrosinase—enzymes crucial for maintaining skin matrix integrity and even tone. Its anti-melanogenic effect is achieved by downregulating the expression of microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein (TRP-1), leading to inhibited melanin synthesis. Additionally, natural polysaccharides function as humectants, attracting moisture for hydration, and its finely ground texture can provide mild exfoliation without causing irritation.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 In organotypic human skin cultures, <1 kDa and 1-3 kDa peptide fractions significantly reduced damage from UVB irradiation. This was achieved by attenuating the depletion of superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, maintaining or increasing catalase (CAT) activity, decreasing pro-inflammatory cytokines (IL-1β, IFN-γ, TNF-α), and inhibiting collagenase, elastase, and tyrosinase activities. The <1 kDa fraction typically exhibited superior protection.
- 02 A 12.5% (wt/vol) ethanol extract significantly reduced ear edema by 31% in a TPA-induced acute skin inflammation model in mice.
- 03 A 25% (wt/vol) ethanol extract demonstrated an even greater anti-inflammatory effect, decreasing ear edema by 48% in the TPA-induced acute skin inflammation mouse model.
- 04 A 1:200 dilution of a 10% (wt/vol) ethanol extract effectively inhibited the secretion of pro-inflammatory cytokines interleukin-1β and tumor necrosis factor-α.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Anthocyanins, key bioactive compounds within red sorghum bran, exhibit remarkable stability across a broad pH range of 1.1 to 10.5, consistently maintaining their color intensity. These compounds are also stable when exposed to light and heat. Utilizing acidic conditions (e.g., pH 2) during extraction can enhance the release of bound phenolic compounds, leading to higher phenolic and flavonoid content, and consequently, increased antioxidant potential in aqueous extracts. However, the specific choice of extraction solvent significantly influences the final composition of polyphenols and flavonoids, and anhydrous methanolic extracts may show different pH sensitivities.
Safety
Safety Profile
No specific safety assessments or opinions from regulatory bodies such as CIR (Cosmetic Ingredient Review), SCCS (Scientific Committee on Consumer Safety), or FDA were identified for SORGHUM BICOLOR BRAN EXTRACT in the provided research.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Sorghum Bicolor Bran Extract is a valuable, multi-functional ingredient offering significant antioxidant, anti-inflammatory, anti-aging, and skin-brightening benefits, supported by human skin culture and in-vivo studies, making it suitable for a wide range of precision skincare applications.
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References
Sources