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Moumoujus

SORBUS COMMIXTA EXTRACT.

Valuable / SKIN CONDITIONING

Sorbus Commixta Extract is a botanical active renowned for its multi-faceted benefits, including significant anti-inflammatory and potent antioxidant properties. It actively protects the skin from environmental stressors like UV radiation and supports healthy skin pigmentation.

Summary

Anti-inflammatory Antioxidant Photo-protective Soothing Melanin synthesis support

Science

Mechanism of Action

Sorbus Commixta Extract operates through several critical pathways to enhance skin health. It exerts robust anti-inflammatory effects by directly suppressing excessive nitric oxide (NO) and prostaglandin E2 (PGE2) production. This involves inhibiting the translocation of NF-κB and its upstream signaling cascades (IKK, Akt, PDK1, PI3K), alongside inhibiting Src and Syk kinases. The extract also reduces the expression of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, and IL-8, while downregulating iNOS and COX-2 mRNA levels. As a potent antioxidant, it effectively scavenges reactive oxygen species (ROS) and demonstrates significant DPPH radical scavenging activity. Furthermore, it offers photo-protective benefits by inhibiting UVB-induced expression of matrix metalloproteinases (MMP-1, MMP-2, MMP-3), which are key contributors to photoaging, potentially through modulation of the MAPK pathway. Interestingly, it can increase the proliferation and melanin content of B16 melanocytes, indicating a role in supporting melanin synthesis and potentially addressing conditions like vitiligo.

Research

Clinical Evidence

Medium confidence
Effective range 1.563–100%
Optimal

N/A

Key findings

  1. 01 Inhibited excessive nitric oxide production in stimulated microglia, demonstrating anti-neuroinflammatory effects.
  2. 02 Reduced UVB-induced MMP-1, MMP-2, MMP-3 expression and intracellular ROS generation in human dermal fibroblasts, indicating anti-photoaging effects.
  3. 03 Demonstrated significant antioxidative properties by suppressing DPPH radical activity in a dose-dependent manner, achieving 86% scavenging at 100 μg/mL.
  4. 04 Increased the proliferation and melanin content of B16 melanocytes and inhibited pro-inflammatory cytokines (IL-6, IL-8, TNF-α) in stimulated dermal fibroblasts and keratinocytes.

Transparency

Dusting Analysis

Not commonly dusted

No data suggests that Sorbus Commixta Extract is commonly included in formulations at sub-efficacious concentrations for marketing purposes. Effective concentrations are well-documented in in vitro studies.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Extracts are generally prepared using polar solvents like water, ethanol, or methanol, indicating that beneficial compounds are soluble in hydro-alcoholic systems. The pH of some stem extracts has been reported around 5.5.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Hot water extracts have shown no hemolytic activity against human red blood cells up to 0.5 mg/ml, and extracts at 1-50 µg/mL did not impair the viability of peripheral blood mononuclear cells, suggesting a favorable safety profile. The SkinSAFE website lists 'Sorbus Commixta Extract' as 'Irritant Free'.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sorbus Commixta Extract is a valuable botanical ingredient offering comprehensive anti-inflammatory, antioxidant, and photo-protective benefits, making it an excellent candidate for formulations targeting skin resilience and overall health.

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