Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

SORBUS COMMIXTA BERRY EXTRACT.

Insufficient Data CAS - / SKIN CONDITIONING

Sorbus Commixta Berry Extract is a botanical ingredient derived from the fruit of the Sorbus commixta tree, recognized for its diverse biological activities. In vitro studies indicate its potential to mitigate inflammation, neutralize oxidative stress, and influence melanin production in skin cells.

Summary

Anti-inflammatory Antioxidant Melanin Modulator Potential Anti-Melanoma Agent

Science

Mechanism of Action

This extract's anti-inflammatory properties stem from its ability to inhibit excessive nitric oxide production and downregulate key pro-inflammatory mediators such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). This action is mediated by the suppression of ERK, JNK, p38 MAPK, and NF-κB pathways. As an antioxidant, it leverages a rich profile of polyphenolic compounds, including chlorogenic acid, rutin, protocatechuic acid, and hydroxybenzoic acid. Furthermore, it displays complex melanin-modulating effects, demonstrating the capacity to increase melanin content and proliferation in melanocytes while also exhibiting anti-melanoma activity by inhibiting the MEK/ERK pathway and activating caspase-3 in cancer cells.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies at 25-100 μg/mL demonstrated significant inhibition of excessive nitric oxide production in lipopolysaccharide-stimulated BV-2 microglia, indicating anti-neuroinflammatory activity.
  2. 02 An ethanol extract at 100 μg/mL in vitro significantly inhibited the proliferation of human melanoma SK-MEL-2 cells by 28.85 ± 3.38%. A butanol fraction showed strong cytotoxic activity against SK-MEL-2 cells with low cytotoxicity against normal human dermal fibroblasts (HDFa) at up to 50 μg/mL.
  3. 03 An ethanol extract in vitro significantly increased the proliferation and melanin content of B16 melanocytes. It also reduced expression levels of IL-6, IL-8, and TNF-α mRNA and proteins in TNF-α-stimulated dermal fibroblasts and keratinocytes.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Ethanol extracts are completely miscible with water. Highly polar components like organic acids and polysaccharides are typically water-soluble, while less polar compounds such as terpenoids and polyphenols are more soluble in organic solvents.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Formal safety assessments by regulatory bodies such as the Cosmetic Ingredient Review (CIR) Expert Panel, EU Scientific Committee on Consumer Safety (SCCS), or FDA specifically for cosmetic use are currently unavailable in the provided data.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Sorbus Commixta Berry Extract demonstrates promising in vitro anti-inflammatory, antioxidant, and melanin-modulating properties, but further human clinical trials and comprehensive safety assessments are required to establish its efficacy and safety for topical use.

Related

Similar Ingredients

Finding similar ingredients…