Science
Mechanism of Action
This extract operates through a synergistic blend of biologically active substances, including various phenolic compounds (such as gallic acid, catechins, ellagic acid, hyperoside, rutin, quercetin-3-D-glucoside, chlorogenic, caffeic, ferulic, and p-coumaric acids, and umbelliferone), ascorbic acid (Vitamin C), carotenoids, and sorbic acid. Its antimicrobial action is largely attributed to sorbic acid, which effectively inhibits the growth of a broad spectrum of bacteria, yeasts, and molds implicated in skin conditions like acne and pyodermitis. As a powerful antioxidant, its high content of polyphenols, flavonoids, and carotenoids diligently neutralizes reactive oxygen species, protecting cellular components from oxidative damage. Furthermore, phenolic compounds contribute to its traditional anti-inflammatory uses, while its inherent properties function as a skin conditioning agent and humectant, promoting moisture retention and maintaining skin health.
Research
Clinical Evidence
High confidence20%
Key findings
- 01 A 20% liquid extract in a lotion demonstrated high antimicrobial activity against *Staphylococcus aureus*, *Staphylococcus epidermidis*, and *Propionibacterium acnes*, bacteria associated with pyodermitis and acne.
- 02 Ethanolic extracts showed potent bactericidal effects against Gram-positive bacteria, including *S. aureus*, MRSA, *Bacillus cereus*, and *Enterococcus faecalis*, at concentrations as low as 0.010 µg/µL.
- 03 Antimicrobial efficacy was also observed against Gram-negative strains, specifically *E. coli* and *Pseudomonas aeruginosa*, at concentrations ranging from 0.043-0.087 µg/µL.
- 04 Significant antioxidant activity was confirmed with an IC50 value of 24.51 ± 0.577 mg/mL in DPPH radical scavenging assays.
Transparency
Dusting Analysis
Insufficient data available to determine if this ingredient is commonly dusted.
The Formula
Formulation
Stability
Optimal antimicrobial efficacy, particularly due to its sorbic acid content, is observed in formulations with a pH below 6.5. A natural color variation during storage, influenced by temperature, may occur.
Safety
Safety Profile
Generally regarded as low-toxic, with in vitro cytotoxicity tests on human peripheral blood mononuclear cells suggesting safety at tested concentrations. However, it's important to note that an in vitro study on renal cells indicated potential cytotoxic activity at a high concentration (19.1 μg/μL), possibly due to pro-oxidant effects from elevated carotenoid levels, warranting careful concentration considerations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Sorbus Aucuparia Fruit Extract is a valuable, multi-functional ingredient providing significant antimicrobial, antioxidant, and conditioning benefits, making it highly suitable for various skin types and concerns within precision skincare formulations.
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