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Moumoujus

SOPHORA FLAVESCENS EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Sophora Flavescens Extract is a botanical active renowned for its potent anti-inflammatory, antibacterial, and skin barrier-strengthening properties. It effectively calms irritation, purifies the skin, and supports healthy moisture levels, making it a multi-functional ingredient for various skin concerns.

Summary

Antioxidant Anti-inflammatory Antimicrobial/Antibacterial Skin conditioning Sebum regulating Barrier enhancement Moisturizing

Science

Mechanism of Action

This extract derives its efficacy from bioactive compounds like flavonoids and alkaloids. Its anti-inflammatory action is mediated by inhibiting the release of inflammatory mediators such as histamine and leukotriene, while also stabilizing cell membranes. Antibacterial effects stem from disrupting bacterial respiration and nucleic acid metabolism, targeting pathogens like Staphylococcus aureus and Propionibacterium acnes. Additionally, it exhibits antioxidant activity, combats free radicals, regulates sebum, and prevents pore clogging. SFE enhances the skin barrier by promoting cornified envelope formation and boosts hydration through upregulation of hyaluronic acid expression. Flavonoids further offer a protective shield against environmental aggressors.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated anti-allergic and anti-inflammatory effects by inhibiting the release of inflammatory mediators (histamine, leukotriene) and stabilizing cell membranes.
  2. 02 Exhibits antibacterial efficacy against Gram bacteria and Staphylococcus aureus, reducing associated pro-inflammatory cytokine production.
  3. 03 Enhances the formation of the cornified envelope, crucial for skin barrier function, and increases hyaluronic acid expression to improve skin moisture, indicating benefits for conditions like atopic dermatitis.
  4. 04 Inhibits pro-inflammatory cytokines induced by substance P, thereby mitigating skin neurogenic inflammation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 7
0 7 14

Stability

Optimal stability for Sophora Flavescens Extract in solution is observed within a pH range of 4.0 to 7.0.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Sophora Flavescens Root Extract is currently on the Cosmetic Ingredient Review (CIR) Expert Panel's '2024 Final Priorities List' for evaluation. While specific SCCS or FDA status is not available, EWG Skin Deep rates it with 'low' concerns for cancer, allergies & immunotoxicity, and developmental and reproductive toxicity. A 'low-moderate' concern for endocrine disruption is noted, referencing studies on flavonoid binding to rat estrogen receptors. Acute and sub-chronic oral toxicity studies in mice and rats suggest a high safety margin when administered orally, with a no-observed-adverse-effect-level (NOAEL) exceeding 1200 mg/kg in rats. However, these are oral studies and not directly translatable to topical application safety at all concentrations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sophora Flavescens Extract is a valuable ingredient, offering significant anti-inflammatory, antibacterial, barrier-supporting, and moisturizing benefits suitable for a broad range of skin types with a low irritancy profile, pending formal CIR review for topical concentrations.

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