Science
Mechanism of Action
This extract exerts its dermatological benefits through several pathways. Mechanistically, it functions as a robust antioxidant and anti-inflammatory agent, notably by inhibiting pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, as well as mediators like NO and PGE-2. It also suppresses the expression of critical inflammatory pathways including TLR-4, COX-2, NF-κB, and pSTAT1. Furthermore, it promotes skin repair and tissue regeneration by influencing collagen formation and contributes to anti-aging by stimulating collagen biosynthesis while inhibiting the activity of matrix metalloproteinase-1 (MMP-1), an enzyme responsible for collagen degradation. The extract also demonstrates antibacterial activity.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The active constituents, including phenolic compounds, flavonoids, glycosides, and carbohydrates, exhibit high water solubility. Extracts show enhanced antioxidant activity, specifically nitrite scavenging effects, at lower pH conditions, suggesting improved stability or efficacy in acidic formulations.
Safety
Safety Profile
Paula's Choice generally classifies 'Sonchus Oleraceus Extract' as non-irritating. While an in vitro cytogenetic assay on A. cepa cells indicated potential genotoxic effects at very high concentrations (above 21.5 mg/mL), antimutagenic efficacy was observed at lower concentrations. An oral toxicity study in mice reported an LD50 > 5g/kg, indicating safety at tested doses with no mortality, suggesting a favorable safety profile for topical cosmetic use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Sonchus Oleraceus Juice Extract is a valuable ingredient, offering broad-spectrum benefits including anti-aging, wound healing, and anti-inflammatory actions, supported by its strong antioxidant capacity and low irritancy profile.
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References
Sources