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Moumoujus

SONCHUS OLERACEUS EXTRACT.

Valuable CAS 96690-50-5 / SKIN CONDITIONING

Sonchus Oleraceus Extract, derived from common sowthistle, is a multi-functional botanical ingredient. It provides significant antioxidant and anti-inflammatory benefits, effectively soothing the skin and protecting against environmental aggressors. Furthermore, a fermented form of this extract has demonstrated potent anti-aging properties by enhancing collagen production and reducing wrinkle appearance.

Summary

Antioxidant Anti-inflammatory Anti-aging Wrinkle Improvement Collagen Booster Wound Healing Antimicrobial Antibacterial

Science

Mechanism of Action

This extract functions as a potent antioxidant by neutralizing free radicals that contribute to skin damage. Its anti-inflammatory action is comprehensive, inhibiting the production of key pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, as well as inflammatory mediators like nitric oxide (NO) and prostaglandin E2 (PGE-2). It achieves this by suppressing critical inflammatory pathways involving TLR-4, COX-2, NF-κB, and pSTAT. A fermented variant specifically enhances anti-aging outcomes by boosting collagen biosynthesis and inhibiting the activity of elastase and MMP-1, enzymes known to degrade skin structure. Additionally, it supports wound healing and exhibits antimicrobial capabilities.

Research

Clinical Evidence

Medium confidence
Effective range 0.001–30%
Optimal

0.01 to 10.0 wt%

Key findings

  1. 01 In an in vitro model, the extract significantly reduced pro-inflammatory cytokines and mediators, while suppressing key inflammatory pathway components (TLR-4, COX-2, NF-κB, pSTAT) in LPS-stimulated RAW 264.7 cells.
  2. 02 In vivo, the extract exhibited significant anti-inflammatory effects in a xylene-induced mouse ear oedema model.
  3. 03 In vitro testing demonstrated concentration-dependent antioxidant activity across various extracts, with specific IC50 values indicating potent free radical scavenging.
  4. 04 A fermented Sonchus Oleraceus L. extract, when incorporated into cosmetic formulations, showed excellent efficacy in improving skin wrinkles by boosting collagen biosynthesis and inhibiting MMP-1.

Transparency

Dusting Analysis

Not commonly dusted

The effective concentration range for Sonchus Oleraceus Extract, particularly its fermented form for anti-aging benefits, is typically between 0.01% and 10.0 wt%. This indicates its use as an active, functional ingredient rather than a trace component often associated with 'dusting'.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Specific optimal pH for overall stability is not detailed, though some research suggests enhanced nitrite scavenging under lower pH conditions. For fermented extracts, concentrations exceeding 30.0 wt% may introduce safety and stability challenges within a formulation.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
30%
Sensitization risk Low

No formal safety assessments from CIR, SCCS, or FDA are currently available. Ecotoxicological models suggest formulations containing the extract are non-toxic at 1000 µg/mL. However, it's important to note a complex dose-dependent effect: high concentrations (e.g., 64.5 mg/mL) showed genotoxic effects in *Allium cepa* cells, while lower concentrations demonstrated antimutagenic activity. For cosmetic applications, a fermented extract is recommended at concentrations between 0.001 wt% and 30.0 wt% to ensure formulation safety and stability.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sonchus Oleraceus Extract is a valuable multi-active botanical ingredient, offering confirmed antioxidant and anti-inflammatory benefits, alongside promising anti-aging effects at recommended concentrations, making it suitable for a wide range of skincare applications.

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