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SODIUM TREHALOSE SULFATE.

Valuable CAS - / HUMECTANT, SKIN CONDITIONING

Sodium Trehalose Sulfate is a specialized sugar derivative engineered to significantly enhance skin hydration and reinforce the epidermal barrier. It actively supports the skin's natural moisturizing factors, leading to a measurable reduction in transepidermal water loss and improved overall skin resilience.

Summary

humectant moisturising water-binding

Science

Mechanism of Action

This ingredient operates by modulating critical epidermal processes at a molecular level. It upregulates mRNA expression of ATP-binding cassette subfamily A member 12 (ABCA12), vital for lipid transport into the stratum granulosum, and filaggrin (FLG), a precursor to Natural Moisturizing Factors (NMFs). Furthermore, it increases enzymes (caspase-14, calpain-1, bleomycin hydrolase) involved in FLG degradation for NMF generation. In 3D skin models, it boosts key proteins like ABCA12, ceramide, transglutaminase1, and FLG, while inducing involucrin (IVL) and transglutaminase1 (TGM1) in the stratum granulosum and upper spinous layers, collectively promoting cellular differentiation for superior barrier function and increased stratum corneum water content.

Research

Clinical Evidence

High confidence
Effective range 0.05–0.2%
Optimal

0.05%

Key findings

  1. 01 A 4-week facial application of a lotion and emulsion containing 0.05% sodium trehalose sulfate decreased transepidermal water loss (TEWL) and increased stratum corneum water content, effectively ameliorating dry skin.
  2. 02 Application of sodium trehalose sulfate solutions to 3D epidermis models significantly increased free amino acid content, indicating enhanced intrinsic moisturizing factors.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 2 – 10
0 7 14

Stability

The parent trehalose molecule demonstrates exceptional stability, tolerating a pH of 2 at 100°C for 24 hours. Aqueous trehalose solutions resist degradation across a pH range of 3-10.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel considers trehalose and related disaccharides safe for cosmetic use. Sodium Trehalose Sulfate is an outstanding active ingredient, generally regarded as non-irritating, with its sodium sulfate component also deemed safe when appropriately formulated.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sodium Trehalose Sulfate is a valuable active ingredient for enhancing skin hydration and barrier function across all skin types, supported by robust clinical data and an excellent safety profile.

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