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SODIUM TOCOPHERYL PHOSPHATE.

Valuable / ANTIOXIDANT, EMULSION STABILISING, REDUCING, SKIN CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING, VISCOSITY CONTROLLING

Sodium Tocopheryl Phosphate is an advanced, water-soluble derivative of Vitamin E, engineered for enhanced stability and bioavailability. Upon topical application, it precisely converts to alpha-tocopherol within the skin, delivering robust antioxidant and anti-inflammatory benefits.

Summary

Antioxidant Anti-inflammatory Photoprotective Antibacterial Moisturizing Skin Brightening

Science

Mechanism of Action

This pro-vitamin form of Vitamin E, known as TPNa, converts to its active alpha-tocopherol state upon absorption into the skin. Its primary actions include potent free radical neutralization, safeguarding the skin from environmental stressors and premature aging. TPNa precisely modulates inflammatory pathways by inhibiting PGE2 production and suppressing cyclooxygenase 2 mRNA expression and p38 MAPK phosphorylation. Furthermore, it exhibits an antibacterial effect against Propionibacterium acnes, supports skin hydration, and contributes to the reduction of melanin production for a more even skin tone.

Research

Clinical Evidence

High confidence
Effective range 1–3%
Optimal

2%

Key findings

  1. 01 Clinical evaluations demonstrate that concentrations starting at 1% provide notable anti-inflammatory effects, while 2-3% delivers significant antioxidant protection.
  2. 02 A 2% concentration effectively mitigated photodamage, including the formation of UVB-damaged cells and PGE2 synthesis, following UVB irradiation.
  3. 03 Pre-treatment with micro-molar concentrations (0-2 μM) dose-dependently inhibited PGE2 production in human epidermal keratinocytes exposed to various pro-inflammatory stimuli.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Sodium Tocopheryl Phosphate exhibits superior stability against light, oxygen, and heat compared to pure vitamin E, making it highly suitable for aqueous formulations such as serums and gels.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has deemed tocopherols and tocotrienols, including Sodium Tocopheryl Phosphate, safe for use in cosmetics, with no specific maximum concentration limits established.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This stable, water-soluble vitamin E derivative is a valuable multifunctional ingredient, offering significant antioxidant, anti-inflammatory, and photoprotective benefits for a wide range of skin concerns.

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