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SODIUM TETRAHYDROJASMONATE.

Valuable / ABRASIVE, SKIN CONDITIONING

Sodium Tetrahydrojasmonate is an advanced, synthetically derived jasmonate analog designed to rejuvenate skin by enhancing its structural integrity and hydration. This multifaceted ingredient works at the cellular level to visibly improve various signs of aging.

Summary

Hyaluronic Acid Synthesis Promotion Collagen and Extracellular Matrix Support Epidermal Renewal Skin Conditioning Anti-aging Texture Improvement Abrasive/Scrub

Science

Mechanism of Action

This compound functions by significantly improving epidermal hyaluronic acid content and thickness. It achieves this by upregulating hyaluronan synthase 2 and 3 expression, leading to increased deposition of hyaluronic acid in the basal and suprabasal epidermal layers. Concurrently, it stimulates the production and deposition of critical structural proteins such as laminin-5, collagen IV, and fibrillin near the dermo-epidermal junction. Additionally, Sodium Tetrahydrojasmonate accelerates desquamation within the upper stratum corneum and enhances its mechanical properties, collectively contributing to a reduction in the appearance of wrinkles and photodamage.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In an open-label prospective clinical trial involving 15 subjects, topical application of a jasmonate complex (LR2412-Cx, containing tetrahydrojasmonic acid) twice daily for 6 weeks yielded statistically significant improvements in facial skin. Participants showed a 7.4% improvement in fine wrinkle appearance, a 12.4% improvement in texture, and a 25.2% improvement in pore appearance. The specific concentration for Sodium Tetrahydrojasmonate was not specified.
  2. 02 In vitro studies demonstrated that tetrahydrojasmonic acid (LR2412), at concentrations of 1 μm and 10 μm, increased the expression of hyaluronan synthase 2 and 3. This led to enhanced hyaluronic acid deposits and stimulated the deposition of laminin-5, collagen IV, and fibrillin in a reconstructed skin model.

Transparency

Dusting Analysis

Not commonly dusted

Given its specific and well-researched mechanism of action in stimulating the production of key extracellular matrix components and hyaluronic acid, alongside positive clinical results, Sodium Tetrahydrojasmonate is considered a valuable active ingredient rather than a 'dusting' ingredient used for marketing claims without substantial benefit.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Jasmonates generally exhibit highest stability in oil-in-water emulsions prepared at 25°C. Hydrogels are also suitable carriers, offering high release rates for the active compound.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) has not yet evaluated Sodium Tetrahydrojasmonate. In the European Union, cosmetic ingredients are subject to stringent safety laws and scientific assessments. In the United States, cosmetic product and ingredient safety is primarily the responsibility of the manufacturing companies, as FDA approval is not typically required before marketing.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sodium Tetrahydrojasmonate is a valuable ingredient for advanced skin rejuvenation, demonstrating significant efficacy in improving hydration, supporting structural integrity, and reducing visible signs of aging with a low irritancy profile.

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