Science
Mechanism of Action
This ingredient operates through a multifaceted mechanism to optimize skin health and integrity. It acts as a potent humectant, actively binding water from the deeper layers of the epidermis to the stratum corneum, thereby increasing intrinsic moisture levels. Concurrently, it forms a protective film on the skin's surface, reducing trans-epidermal water loss and acting as an occlusive agent. Lower molecular weight fractions are capable of penetrating the stratum corneum to deliver conditioning benefits, while higher molecular weight components establish a reinforcing barrier. This action collectively improves skin moisturization, elasticity, and feel, reinforcing the skin barrier's integrity and enhancing its water-holding capacity. Additionally, it offers mild surfactant properties, contributing to skin conditioning, lubrication, and softness.
Research
Clinical Evidence
High confidenceEffective at 2-4% for significant hydration and barrier benefits.
Key findings
- 01 Clinical studies demonstrate that a 2% concentration of keratin hydrolysate, when formulated in an ointment base, can increase stratum corneum hydration by 14% to 23%.
- 02 A 4% concentration of the keratin hydrolysate in an ointment base has been shown to decrease trans-epidermal water loss by 26% to 46%, indicating substantial barrier reinforcement.
- 03 An efficacy study utilizing 3% hydrolyzed keratin in a hand cream reported no adverse effects, confirming its safety and tolerability at functional concentrations.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
SODIUM/TEA-LAUROYL HYDROLYZED KERATIN is generally stable under typical storage conditions, requiring protection from excessive heat and moisture. When incorporated into ointment bases, it has demonstrated stability without phase separation for periods up to 6 months. An optimal pH range of 5.0 to 7.5 is recommended for maintaining its integrity and suitability in skin applications.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has affirmed keratin-derived ingredients, including Hydrolyzed Keratin, as safe for use in cosmetics at present concentrations. Human studies consistently show non-irritating properties at concentrations up to 25%. In vitro tests at 100% and rabbit studies also indicated minimal to no irritation. Ocular irritation was not observed at concentrations up to 5%, with only slight potential noted at 10%. Furthermore, patch studies at up to 5% concentration revealed no evidence of skin sensitization.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SODIUM/TEA-LAUROYL HYDROLYZED KERATIN is a valuable ingredient for enhancing skin hydration, reinforcing barrier function, and improving overall skin texture and elasticity, supported by robust safety data.
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