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Moumoujus

SODIUM POLYGLUTAMATE.

Valuable CAS 28829-38-1 / HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING

Sodium Polyglutamate is a sophisticated humectant derived from fermented soybeans, celebrated for its superior ability to attract and retain moisture. It not only intensely hydrates the skin but also works to prevent water loss, promoting a visibly smoother, plumper, and more elastic complexion.

Summary

Humectant Skin-Conditioning Agent Antioxidant Brightening Agent Elasticity Enhancer NMF Booster

Science

Mechanism of Action

This potent humectant operates by creating a breathable, water-retaining film on the skin's surface, significantly reducing transepidermal water loss (TEWL) and enhancing barrier function. Beyond surface hydration, Sodium Polyglutamate actively inhibits hyaluronidase (HYAL1), an enzyme that degrades the skin's natural hyaluronic acid, thereby preserving endogenous HA levels for prolonged moisture. Furthermore, it upregulates the expression of filaggrin and ceramide synthase genes, boosting the skin's production of natural moisturizing factors (NMFs). Its antioxidant properties neutralize free radicals, while a potential to inhibit tyrosinase activity contributes to a brighter, more even skin tone.

Research

Clinical Evidence

High confidence
Effective range 0.05–3%
Optimal

0.3%

Key findings

  1. 01 Continuous use for 14 days demonstrated a 26.7% reduction in transepidermal water loss (TEWL), outperforming the control group.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.05%
Red flag below
0.05%

Sodium Polyglutamate is a highly active ingredient. Efficacy has been demonstrated at concentrations as low as 0.3% in clinical settings, with recommended usage rates starting from 0.05%. Formulations containing less than 0.05% are unlikely to deliver its full spectrum of benefits, indicating potential 'dusting' where an ingredient is included for marketing claims rather than functional effect.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7.5
0 7 14

Stability

This ingredient exhibits excellent stability across a broad pH range, from mildly acidic (pH 5.0) to moderately alkaline (pH 7.5), ensuring compatibility with diverse formulation types including vitamin C serums, AHA/BHA treatments, and soap-based cleansers. It also shows robust heat stability and resistance to microbial degradation, contributing to product longevity.

Synergies

  • Vitamin C (ascorbic acid)
  • Alpha Hydroxy Acids (AHAs)
  • Beta Hydroxy Acids (BHAs)
  • Hyaluronic Acid (for enhanced hydration retention)
  • Ceramides (for barrier support)

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
3%
Sensitization risk Low

Generally considered safe and well-tolerated across most skin types, with an EWG rating of 1. Clinical application of Sodium Polyglutamate formulations has not been associated with irritation or rashes. Concentrations exceeding 3% are not recommended as they may potentially weaken cutaneous tissues and induce redness.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Sodium Polyglutamate is a valuable active, offering superior hydration, barrier protection, and potential anti-aging and brightening benefits, making it an excellent addition to precision skincare formulations.

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