Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle

SODIUM PALMITOYL PROLINE.

Valuable CAS 58725-33-0 / SKIN CONDITIONING

Sodium Palmitoyl Proline is an innovative amphiphilic amino-acid derivative, expertly combining palmitic acid with L-proline. This unique structure allows it to effectively interact with both lipid and aqueous skin phases, delivering comprehensive conditioning and soothing benefits. It visibly improves skin texture, strengthens the barrier, and reduces discomfort, making it a cornerstone for advanced skincare formulations.

Skin-conditioning Soothing Brightening Anti-aging Moisturizing Skin-softening Promotes skin regeneration Mild anti-inflammatory Maintains pH balance Strengthens skin's protective barrier

Science

This amphiphilic molecule, derived from L-proline and palmitic acid, readily integrates with the skin's lipid interfaces and aqueous components. It primarily functions as a conditioning agent, enhancing the skin's natural moisturizing factor and softening texture, which contributes to improved smoothness and elasticity. It actively promotes skin regeneration and exhibits a mild anti-inflammatory action, helping to stabilize the skin's natural pH and reduce irritation. By reinforcing the skin's protective barrier, it optimizes moisture retention and bolsters defense against environmental aggressors. Notably, in sensitive skin, it provides soothing relief without compromising the lipid layer. When complexed with Nymphaea alba flower extract, it precisely targets stress-induced pigmentation and basal melanogenesis through specific gene modulation (upregulating MIC-1, downregulating MITF/tyrosinase) and effectively mitigates inflammatory responses. Its proline component is also vital for supporting collagen synthesis and maintaining skin elasticity.


Research

Medium confidence
Effective range 3–3%
Optimal

3%


Transparency

Not commonly dusted

No data available regarding 'dusting' or common over-formulation practices for this ingredient.


The Formula

Solubility
Both
Optimal pH N/A
0 7 14

Stability

While the raw material exhibits sparingly solubility in water, it can be efficiently incorporated into formulations through glycol-based concentrates or microemulsions. For optimal performance when complexed with Nymphaea alba extract, pre-heating to 40°C is recommended before use. However, excessive heat should be avoided to preserve the efficacy of the water lily extract. Formulations should utilize stabilizers capable of resisting electrolytes.

Synergies

  • Nymphaea alba (white water-lily) flower extract (enhances brightening and soothing effects)

Conflicts

  • strong oxidants (for solid raw material form)

Safety

CIR Status
Safe with restrictions
Sensitization risk Low

Recognized as safe for use in cosmetic products by regulatory bodies such as the European Cosmetics Regulation, provided that established concentration limits are diligently observed. The Cosmetic Ingredient Review (CIR) has also deemed it safe under specific use limitations. While generally well-tolerated, rare instances of allergic reactions or skin sensitivity have been reported. It is a publicly recorded ingredient with the FDA.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

Sodium Palmitoyl Proline is a valuable multi-functional ingredient for Moumoujus, offering significant benefits for robust skin conditioning, soothing sensitive skin, and effectively addressing hyperpigmentation concerns.


Related

Finding similar ingredients…