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SODIUM PALMITOYL CHONDROITIN SULFATE.

Insufficient Data CAS 226995-63-7 / HAIR CONDITIONING, SKIN CONDITIONING

A specialized derivative of Chondroitin Sulfate, this ingredient functions as a potent humectant and glycosaminoglycan (GAG), adept at binding water to significantly boost skin hydration. It actively forms a protective moisture barrier while also supporting the regeneration of vital skin mucopolysaccharides for a revitalized appearance.

Summary

Humectant Skin Conditioning Protective Film Formation Anti-inflammatory Replenishes Mucopolysaccharides Supports Skin Regeneration Antistatic Hair Conditioning Provides Support and Volume (when combined with other ingredients) Plumping

Science

Mechanism of Action

As a modified Chondroitin Sulfate, Sodium Palmitoyl Chondroitin Sulfate operates primarily as a powerful humectant, drawing and retaining moisture within the skin, much like hyaluronic acid. It forms a resilient, protective film on the skin's surface to prevent transepidermal water loss and ensure sustained hydration. Beyond its humectant properties, it contributes to the replenishment and regeneration of aged mucopolysaccharides, supporting skin's natural structure and promoting a healthier, rejuvenated look. The ingredient also possesses anti-inflammatory capabilities and, when integrated into advanced delivery systems, can collaborate with components like vegan collagen and hyaluronic acid to construct a 'scaffold' within the skin, visibly enhancing support, volume, and reducing the appearance of fine lines and wrinkles.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5.5 – 7.5
0 7 14

Stability

Aqueous solutions of Sodium Chondroitin Sulfate generally maintain stability within a pH range of 5.5 to 7.5. This ingredient is hygroscopic, meaning it readily absorbs moisture from the air, which should be considered during handling and storage. Variability in sulfate content and molecular weight among different chondroitin sulfate preparations may influence its biological activity and formulation performance.

Synergies

  • Vegan Collagen
  • Hyaluronic Acid

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not yet specifically reviewed Sodium Palmitoyl Chondroitin Sulfate. While its non-palmitoylated counterpart, Chondroitin Sulfate Sodium, holds a Generally Recognized As Safe (GRAS) status by the FDA for food and drug applications (with a daily intake limit of 1200 mg/person), this status does not directly extend to the palmitoylated form's cosmetic use. More specific research on the safety profile of Sodium Palmitoyl Chondroitin Sulfate in topical applications is needed.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

This ingredient shows promising humectant, regenerative, and structural support potential, but requires further specific clinical efficacy and safety review for its palmitoylated form to fully assess its optimal contribution to precision skincare.

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