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Moumoujus

SODIUM MANNOSE PHOSPHATE.

Valuable CAS 70442-25-0 / HUMECTANT, SKIN CONDITIONING

Sodium Mannose Phosphate is a sophisticated sugar derivative recognized for its multifaceted benefits in skin rejuvenation. It actively works to restore skin's structural integrity, visibly reducing the appearance of wrinkles and enhancing firmness, while simultaneously boosting hydration and barrier function.

Summary

anti-aging skin firming wrinkle reduction humectant skin conditioning moisturizing barrier strengthening

Science

Mechanism of Action

This ingredient operates by strategically reorganizing the dermal collagen network, thereby improving the skin's inherent biomechanical properties. It safeguards crucial dermal proteins from oxidative stress and degradation, which is critical for maintaining skin's elasticity and reducing the formation of lines. Additionally, Sodium Mannose Phosphate contributes to optimal skin hydration and strengthens the epidermal barrier, promoting a soothed complexion. Related D-Mannose further supports skin health by modulating inflammatory pathways, thereby diminishing redness and discomfort.

Research

Clinical Evidence

Medium confidence
Effective range 2–4%
Optimal

2%

Key findings

  1. 01 A 4% mannose-6-phosphate complex, containing 2.0% to 4.0% Sodium Mannose Phosphate, significantly improved the mechanical properties of mature skin and reorganized the collagen fiber network, leading to increased skin firmness. Clinical results demonstrated a 32.5% reduction in neck wrinkle size after 28 days (23.2% after 56 days) and an 8.2% reduction in neck wrinkle depth after 28 days (8.3% after 56 days).

Transparency

Dusting Analysis

Not commonly dusted

Given its demonstrated efficacy at specific concentrations in clinical settings, Sodium Mannose Phosphate is not identified as an ingredient commonly 'dusted' at sub-efficacious levels.

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

Sodium Mannose Phosphate (as d-Mannose-6-phosphate, sodium salt) exhibits stability within a pH range of 4.0 to 7.0, as observed during its purification process.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

Sodium Mannose Phosphate is generally considered safe for cosmetic use. It was included in a 'Draft Report for Panel Review' by the Cosmetic Ingredient Review (CIR) Expert Panel. While a specific maximum concentration for this exact ingredient is unknown from the provided data, a related ingredient, Mannose, was deemed safe by CIR in concentrations up to 5%.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

A valuable active, Sodium Mannose Phosphate is highly recommended for its scientifically backed ability to enhance skin firmness, reduce visible wrinkles, and support overall skin health across diverse skin types.

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