Science
Mechanism of Action
This chemically modified cyclodextrin possesses a unique structure with a hydrophilic exterior and a lipophilic internal cavity, enabling it to form inclusion complexes with hydrophobic molecules. This encapsulation protects active ingredients from degradation by light and and heat, boosts their water solubility, and optimizes their bioavailability and sustained release on the skin. Beyond its encapsulation prowess, it functions as a humectant, attracting and retaining moisture, and serves as a surfactant for gentle cleansing. It also stabilizes emulsions and helps mitigate undesirable body odors.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient exhibits excellent stability in solution across a broad pH range of 3.0 to 9.0, maintaining integrity under stress conditions such as elevated temperature (40°C) and high oxygen pressure.
Conflicts
- Polysorbate 80 (PS80)
- Polysorbate 20 (PS20)
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel noted 'insufficient data' for Sodium Hydroxypropyl Cyclodextrin Octenylsuccinate itself, despite proposing its inclusion in a broader assessment of related ingredients in 2018. While a specific 'safe as used' conclusion or maximum concentration has not been established for this ingredient, other cyclodextrins like native cyclodextrins, 2-hydroxypropyl-β-cyclodextrin, and hydroxyethyl-β-cyclodextrin are endorsed as safe by the CIR. Furthermore, the Scientific Committee on Consumer Safety (SCCS) in the EU classifies cyclodextrins as excipients, and the FDA recognizes native cyclodextrins as generally safe (GRAS) for food use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While offering significant benefits in ingredient stabilization, solubility, and hydration across all skin types, comprehensive safety data for Sodium Hydroxypropyl Cyclodextrin Octenylsuccinate itself is currently insufficient according to the CIR Expert Panel.
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