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SODIUM HISTIDYL HYALURONATE CROSSPOLYMER-3.

Valuable / HUMECTANT, SKIN CONDITIONING

SODIUM HISTIDYL HYALURONATE CROSSPOLYMER-3 is an advanced, cross-linked form of hyaluronic acid engineered for superior and sustained skin hydration. It creates a resilient, interconnected mesh structure on the skin's surface, significantly enhancing water retention and reinforcing the skin's natural barrier function.

Summary

Humectant Skin conditioning Barrier support Antioxidant Anti-aging

Science

Mechanism of Action

This sophisticated ingredient functions as a highly effective humectant and skin conditioning agent. Its unique cross-linked molecular structure forms an interconnected mesh, capable of binding up to five times more water than conventional hyaluronic acid. This network continuously draws moisture from the atmosphere and delivers it to the epidermis, while simultaneously forming a smooth, protective film. This film effectively prevents trans-epidermal water loss (TEWL), lubricates the skin, and strengthens the skin barrier. The cross-linking also confers enhanced stability and resistance to enzymatic degradation, ensuring a prolonged presence on the skin for extended hydration and contributing to a reduction in the appearance of fine lines and wrinkles. Additionally, it exhibits antioxidant properties and supports healthy skin cell turnover.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Topical application of a crosslinked Resilient Hyaluronic Acid (RHA), representative of this ingredient's class, demonstrated a significant 7.6% increase in epidermal water content over control. It also led to a substantial 27.8% reduction in transepidermal water loss (TEWL), indicating superior hydration and improved barrier function compared to linear high molecular weight (HMW) or low molecular weight (LMW) hyaluronic acid.

Transparency

Dusting Analysis

Not commonly dusted

Insufficient specific data to suggest this ingredient is commonly used at ineffective concentrations solely for marketing purposes. Its established mechanism of action and clinical findings support its potential for efficacy at appropriate inclusion levels.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The cross-linked nature of Sodium Histidyl Hyaluronate Crosspolymer-3 significantly enhances its stability, allowing for seamless integration into diverse product formulations such as serums, creams, and lotions. It exhibits superior resistance to enzymatic degradation compared to classic hyaluronic acid, ensuring prolonged efficacy.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

While no explicit Cosmetic Ingredient Review (CIR) assessment specifies SODIUM HISTIDYL HYALURONATE CROSSPOLYMER-3, it falls under the broader category of hyaluronate ingredients. The CIR Expert Panel has deemed Hyaluronic Acid, Potassium Hyaluronate, and Sodium Hyaluronate as safe for cosmetic use, with cross-linked forms generally considered non-toxic, non-irritating, and posing a low risk of allergic reactions.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

SODIUM HISTIDYL HYALURONATE CROSSPOLYMER-3 is a valuable ingredient for superior, long-lasting hydration, barrier reinforcement, and anti-aging benefits across all skin types, thanks to its unique cross-linked structure.

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