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SODIUM DNA.

Valuable / SKIN CONDITIONING

Sodium DNA, also known as Polydeoxyribonucleotide (PDRN), is a powerful biomolecule engineered for advanced skin regeneration. It operates at a cellular level to significantly enhance natural repair processes, improving skin's structural integrity, elasticity, and overall vitality.

Antioxidant Skin-Restoring Wound Healing Regenerative Anti-aging Collagen Boosting Melanin Inhibitor

Science

Functioning as a potent regenerative agent, Sodium DNA is absorbed by skin cells to facilitate the synthesis of new DNA and RNA, thereby accelerating cellular turnover and promoting comprehensive regeneration. It actively stimulates cellular repair mechanisms, fosters the regeneration of epithelial and granulation tissues, and reduces inflammatory responses to expedite wound healing. As a robust antioxidant, it neutralizes free radicals, protecting skin cells from oxidative stress. Sodium DNA fortifies the epidermal barrier, stimulates cell proliferation, and demonstrably enhances skin elasticity, thickness, and hydration. Furthermore, it activates toll-like receptors (TLR-9) to promote the production of critical growth factors such as TGF-β, VEGF, and EGF, which are essential for robust fibroblast activity and collagen synthesis. Its multifaceted action also includes improving microcirculation, inhibiting melanin formation for a more uniform complexion, and modulating immune responses to augment cellular repair, including reducing UV-induced damage and promoting DNA repair via the p53 protein pathway.


Research

Medium confidence
Effective range N/A
Optimal

0.36%


Transparency

Not commonly dusted

There is no specific data indicating Sodium DNA is commonly dusted or misused in formulations.


The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Stability

As a sodium salt, Sodium DNA exhibits enhanced stability, allowing for extended shelf life by neutralizing the DNA's negative charges. Formulations should consider salt concentrations; native DNA sodium salt can degrade below approximately 0.1%, while concentrations exceeding 0.9% by weight may impede filtration.


Safety

CIR Status
Not reviewed
Sensitization risk Low

Sodium DNA is generally recognized as safe for topical cosmetic use, demonstrating low potential for irritation and allergenicity in clinical assessments. While adverse reactions are rare, patch testing is advisable. Phototoxicity tests confirm a lack of cytotoxic effects. EWG Skin Deep classifies Sodium DNA with a 'LOW' hazard rating across cancer, allergy/immunotoxicity, and developmental/reproductive toxicity concerns.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Sodium DNA is a valuable and innovative ingredient for precision skincare, offering comprehensive regenerative, anti-aging, and repairing benefits with a strong safety profile across all skin types.


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