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SODIUM DILAURAMIDOGLUTAMIDE LYSINE.

Valuable CAS - / HUMECTANT

Sodium Dilauramidoglutamide Lysine is a precision amino acid-derived lipid, structurally similar to the skin's natural ceramides. It functions as a potent humectant, a stable emulsifier, and a significant skin penetration enhancer. This ingredient visibly repairs and softens the skin while optimizing the delivery of co-formulated active compounds.

Summary

Humectant Emulsifying Skin-softening Permeation Enhancer Surfactant Skin Renewal Skin Barrier Support

Science

Mechanism of Action

This unique ingredient interacts synergistically with the skin's inherent biological processes. As a humectant, it efficiently attracts and retains atmospheric moisture, leading to enhanced skin hydration. Its ceramide-like structure allows for effective integration with the skin barrier, supporting repair mechanisms and facilitating cellular renewal through its surfactant properties. Crucially, it acts as a permeation enhancer, promoting the accumulation and dermal absorption of hydrophilic compounds within the skin, thereby maximizing the efficacy of other beneficial actives. It also aids in the gentle shedding of dead skin cells, contributing to a softer, smoother, and more moisturized skin appearance while offering protection against acne.

Research

Clinical Evidence

High confidence
Effective range 0.1–1%
Optimal

0.1%

Transparency

Dusting Analysis

Not commonly dusted

Given its demonstrated efficacy at concentrations as low as 0.1% for both skin repair and emulsification, and its significant permeation-enhancing capabilities within a formulation, Sodium Dilauramidoglutamide Lysine is highly functional even at minimal inclusion levels. This suggests its use is typically purposeful, rather than for 'dusting' simply to appear on an ingredient list.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Expected to maintain stability under normal conditions of use. While pH stability studies have been conducted, specific optimal pH range data were not detailed in the available research.

Synergies

  • Hydrophilic active compounds (e.g., L-ascorbic acid 2-glucoside) due to its proven permeation-enhancing capabilities, leading to improved delivery and efficacy.
  • Other moisturizing agents, to create a more robust and lasting hydration effect.

Conflicts

  • Formulators should exercise due care when using it in conjunction with other dermal penetration enhancers, or with ingredients whose increased dermal absorption could lead to unintended or undesirable effects, due to its ability to enhance the permeation of other chemicals in a formulation.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
1%
Sensitization risk Low

The ingredient is not considered to pose an unreasonable risk to public health when used at concentrations up to 1% in cosmetic products. It has been shown to be non-irritating to the skin at concentrations up to 10% and non-irritating to the eyes at concentrations up to 1%. However, due to its surfactant properties, potential irritation effects at concentrations exceeding 1% cannot be definitively ruled out without further data. It is listed as 'Irritant Free' by SkinSAFE. It is not a drug, therefore a specific pregnancy risk category (N/A) is not assigned.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sodium Dilauramidoglutamide Lysine is a valuable, multi-functional ingredient that significantly enhances hydration, supports skin barrier repair, and optimizes the dermal delivery of other active compounds, positioning it as a powerful asset for advanced skincare formulations.

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