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Moumoujus

SODIUM DERMATAN SULFATE.

Valuable CAS - / SKIN CONDITIONING

Sodium Dermatan Sulfate is a critical glycosaminoglycan naturally present in skin, essential for maintaining the dermal extracellular matrix. It significantly enhances skin hydration, supports the synthesis of vital structural proteins, and plays a key role in the skin's intrinsic repair and regeneration processes. Its presence is integral to preserving youthful skin functionality and combating the visible markers of aging.

Summary

Humectant Skin-identical ingredient Anti-aging Wound healing Skin regenerating Elasticity enhancing Collagen booster

Science

Mechanism of Action

As a polyanionic glycosaminoglycan, Sodium Dermatan Sulfate (DS) profoundly influences skin health by boosting hydration through its exceptional water-retention capacity. It actively stimulates the proliferation of dermal fibroblasts and keratinocytes, facilitating regeneration and re-epithelialization during wound healing. DS also increases the production of crucial extracellular matrix components, including type III collagen and elastin, while regulating collagen assembly, thereby enhancing skin elasticity and structural integrity. Its function as a cofactor for various growth factors further supports neovascularization and overall dermal functionality. A decline in DS levels is directly linked to intrinsic skin aging, resulting in dermal thinning.

Research

Clinical Evidence

Medium confidence
Effective range 0.005–0.25%
Optimal

0.25%

Key findings

  1. 01 In vitro studies demonstrated that concentrations of 0.005% to 0.008% (50-80 μg/mL) of 2,4-dermatan sulfate significantly accelerated wound closure and promoted cellular dispersion within 24-48 hours, thereby reducing healing time.
  2. 02 In vivo research on C57BL/6 mice revealed that topical application of 0.25% 2,4-dermatan sulfate to experimental wounds led to substantial improvements in vascular recovery.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

As a polyanionic glycosaminoglycan, Sodium Dermatan Sulfate is highly water-soluble. Specific optimal pH ranges for cosmetic formulation stability are not detailed in current research; however, glycosaminoglycans typically exhibit stability in aqueous environments.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Sodium Dermatan Sulfate has not undergone specific review by the Cosmetic Ingredient Review (CIR) panel or the SCCS. While systemic dermatan sulfate (e.g., as Sulodexide) has been linked to potential Drug-Induced Liver Injury (DILI), this concern applies to internal drug use and is not relevant to its topical application in cosmetic formulations. No maximum safe topical concentration has been formally established, and existing data offers no indications of topical safety concerns.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sodium Dermatan Sulfate is a valuable glycosaminoglycan that significantly boosts skin hydration, elasticity, and regeneration, making it a powerful component for anti-aging and reparative formulations.

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