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SODIUM CARBOXYMETHYL DEXTRAN ACETATE SULFATE.

Insufficient Data / HUMECTANT, NAIL CONDITIONING, SKIN PROTECTING

A complex carbohydrate derivative, SODIUM CARBOXYMETHYL DEXTRAN ACETATE SULFATE is designed to enhance skin hydration, offering humectant properties to attract and retain moisture. It also provides protective benefits and supports skin soothing, while contributing to improved product texture and stability.

Summary

Humectant Skin Protecting Nail Conditioning Anti-inflammatory Soothing Stabilizer Texture Enhancer Gel-forming Binding

Science

Mechanism of Action

This ingredient functions primarily as a humectant, drawing moisture into the skin to maintain optimal hydration levels. Its dextran sulfate component may stimulate nitric oxide synthesis in epidermal keratinocytes, which can improve microcirculation and help reduce visible swelling. Furthermore, dextran sulfate exhibits anti-inflammatory effects that can calm irritated skin. The carboxymethyl dextran aspect further supports moisturizing capabilities, acts as a stabilizing agent within formulations, and enhances the overall sensory texture of products.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 10
0 7 14

Stability

The underlying dextran structure generally maintains stability at ambient temperatures across a pH range of 4 to 10, with optimal storage conditions observed between pH 6 and 7. Carboxymethyl dextran also demonstrates stability across various pH and temperature conditions, and dextran sulfates are inherently stable in aqueous solutions.

Conflicts

  • Polycations (due to the polyanionic nature of its dextran sulfate component)

Safety

Safety Profile

CIR Status
Unknown
Sensitization risk Unknown

Direct safety assessments by the CIR, SCCS, or FDA for SODIUM CARBOXYMETHYL DEXTRAN ACETATE SULFATE are not available. However, its component, Sodium Dextran Sulfate, has been deemed safe by the independent CIR panel for use in leave-on cosmetics at concentrations up to 0.5%. Carboxymethyl Dextran is also considered safe due to its inherent biocompatibility and non-toxic profile. It is important to note that observations of Dextran Sulfate Sodium inducing colitis in animal models at high oral doses (1-5%) are specific to that experimental context and not applicable to topical cosmetic use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While SODIUM CARBOXYMETHYL DEXTRAN ACETATE SULFATE shows promising mechanistic benefits for hydration, soothing, and protection based on its components, direct safety and efficacy data for the complete ingredient are currently insufficient to provide a definitive assessment.

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