Science
Mechanism of Action
The efficacy of SODIUM CALCIUM BORON PHOSPHATE on the skin is attributed to its individual components. Boron, in forms distinct from boric acid, is associated with a range of beneficial effects including antimicrobial action, modulation of inflammatory responses, reduction of oxidative stress, and promotion of angiogenesis. It further supports anti-fibrotic properties by stimulating fibroblast proliferation, migration, and extracellular matrix turnover, such as collagen synthesis, which is crucial for wound healing and overall skin structure. Boron compounds also show potential for skin rejuvenation, aiming to decrease wrinkle depth, enhance skin thickness, improve hydration, softness, and elasticity, and diminish the appearance of age spots and discolorations. Calcium and phosphate are fundamental minerals essential for numerous physiological skin functions. Phosphates, like sodium phosphate, are known to regulate pH and contribute to maintaining the skin's moisture barrier. As an abrasive, the compound can facilitate exfoliation.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The compound is water-soluble. Calcium phosphates typically exhibit reduced solubility in neutral and alkaline conditions, becoming more soluble in acidic environments. Sodium phosphate is well-regarded for its ability to regulate pH and stabilize cosmetic formulations. Boron-phosphate glass systems have demonstrated localized pH regulation within the range of 5.5 to 9.8.
Conflicts
- Likely precipitation with calcium phosphate at lower pH and higher concentrations, as observed in complex solutions like parenteral nutrition.
Safety
Safety Profile
While SODIUM CALCIUM BORON PHOSPHATE has not undergone a dedicated CIR Expert Panel review, its constituent components have. Phosphoric acid and its salts, including calcium phosphate and sodium phosphate, have been deemed safe for use in cosmetics under current practices and concentrations, provided they are formulated to be non-irritating. However, Sodium Borate and Boric Acid were previously considered safe at concentrations of 5% or less in cosmetic products, with a critical caveat against use on infant or injured skin. In June 2024, the CIR panel reopened the safety assessment of Sodium Borate and Boric Acid to evaluate new data and investigate the reasons behind their regulatory ban by the European Union (EU), indicating potential regulatory concerns. The Scientific Committee on Consumer Safety (SCCS) has also issued opinions on boron compounds, reflecting these EU regulatory concerns. The FDA has confirmed calcium phosphate as safe for use as a color additive in certain food products. Warnings associated with oral sodium phosphate laxatives for acute phosphate nephropathy are not applicable to topical cosmetic use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While offering diverse theoretical benefits for skin health and rejuvenation, this compound lacks specific clinical and safety reviews as a combined ingredient, and the regulatory uncertainty surrounding its boron component warrants a cautious approach.
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