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SODIUM ACETYLATED HYALURONATE.

Essential / HUMECTANT

Sodium Acetylated Hyaluronate is an advanced hyaluronic acid derivative engineered for superior skin penetration and sustained hydration. Its unique amphipathic structure allows it to bind effectively, providing lasting moisture and significantly enhancing skin elasticity and smoothness.

Summary

Moisturizer Humectant Skin-identical ingredient Anti-aging agent Skin barrier support Elasticity booster Wrinkle reduction

Science

Mechanism of Action

This modified form of hyaluronic acid undergoes acetylation, introducing acetyl groups that confer both lipophilic and hydrophilic properties, making it amphipathic. This dual affinity significantly improves its interaction with the skin, enabling deeper and faster absorption into the stratum corneum compared to traditional HA. It anchors firmly to the skin's surface, forming a stable, protective layer that effectively minimizes transepidermal water loss (TEWL) for over 12 hours. Additionally, it promotes epidermal cell proliferation, aids in repairing damaged skin, reinforces the skin's natural barrier, boosts elasticity, and exhibits enhanced resistance to enzymatic degradation by hyaluronidases.

Research

Clinical Evidence

High confidence
Effective range 0.05–1%
Optimal

0.1%

Transparency

Dusting Analysis

Not commonly dusted

Sodium Acetylated Hyaluronate is a highly efficacious active ingredient with robust clinical data supporting its benefits, particularly its enhanced skin affinity and superior hydration. It is generally incorporated at effective percentages and not typically used for 'dusting' or minimal inclusion.

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 8
0 7 14

Stability

Stable within a pH range of 4.0 to 8.0. Extreme pH values (acidic or basic) and elevated temperatures can accelerate depolymerization, potentially reducing viscosity and efficacy. Heating should be avoided or minimized during formulation to prevent degradation. Full stability should be meticulously validated within the final product's specific pH, and in the presence of any chelators, preservatives, or other active ingredients.

Conflicts

  • Strongly cationic ingredients (especially under extreme pH conditions, which may lead to precipitation or activity loss)
  • Strong oxidizing agents

Safety

Safety Profile

CIR Status
Safe as used
Max tested
1%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded in 2023 that hyaluronate ingredients, including Sodium Acetylated Hyaluronate, are safe for use in cosmetics at current practices and concentrations, with typical use in leave-on facial products ranging from 0.05% to 1.0%. No known adverse side effects have been reported; however, individuals with particularly sensitive skin are advised to consult a dermatologist prior to use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Essential

Sodium Acetylated Hyaluronate is an indispensable hydrating and anti-aging active, delivering superior, long-lasting moisture and visible wrinkle reduction due to its enhanced skin affinity and stability.

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