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Moumoujus

SMILAX UTILIS ROOT EXTRACT.

Insufficient Data CAS 84961-59-1 / SKIN CONDITIONING

Smilax Utilis Root Extract is a botanical ingredient recognized for its multifaceted benefits, including significant soothing and antioxidant properties. It aids in calming skin irritation and fortifying the skin's defense against environmental stressors. This extract also offers potential for enhancing skin hydration, elasticity, and overall resilience.

Summary

Soothing Antioxidant Anti-inflammatory Antimicrobial Skin conditioning Moisturizing Enhances elasticity Anti-itching (Anti-pruritic) Immunomodulatory Potential anti-acne Potential anti-psoriasis

Science

Mechanism of Action

This extract modulates skin health through several pathways. It exhibits soothing effects by downregulating pro-inflammatory cytokines in keratinocytes, thereby alleviating irritation. Its antioxidant capabilities are demonstrated by inducing antioxidant enzymes in human dermal fibroblasts, protecting against free radical damage and mitigating premature aging. Phenolic acids within Smilax contribute to antimicrobial action, targeting bacteria like Staphylococcus aureus and potentially aiding in conditions such as acne. Furthermore, steroidal glycosides are implicated in inflammation modulation, complementing its immunomodulatory and anti-pruritic actions. The extract may also support skin purification by stimulating cellular waste removal, potentially benefiting conditions like psoriasis.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Downregulation of pro-inflammatory cytokines in keratinocytes (in vitro study, for Smilax Utilis Root Extract).
  2. 02 Significant in vivo antioxidant activity in Wistar rats (for ethanolic extract from Smilax zeylanica roots).
  3. 03 Antibacterial activity against Staphylococcus aureus (for Smilax glabra extract components).
  4. 04 Antibacterial activity against Candida albicans (for Smilax glabra extract components).
  5. 05 Inhibition of α-glucosidase and α-amylase activity (for Smilax aristolochiifolia root extract and its fractions).

Transparency

Dusting Analysis

Not commonly dusted

There is no indication that Smilax Utilis Root Extract is commonly 'dusted' or used at sub-efficacious percentages for marketing purposes. Its complex profile suggests its inclusion would be for targeted benefits.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Research indicates stability in a phosphate buffer at pH 6.9 for enzyme inhibition studies, suggesting suitable stability within this pH range for research purposes.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

Specific safety assessments for Smilax Utilis Root Extract in cosmetics by CIR or SCCS are not available. EWG classifies this ingredient as 'RESTRICTED' for EWG VERIFIED products without adequate substantiation and reports 'No Data' for several safety concerns, including skin allergies and irritation. While the FDA permits related Smilax species extracts as natural flavoring in food, this does not directly translate to cosmetic safety profiles.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Smilax Utilis Root Extract demonstrates promising in vitro anti-inflammatory mechanisms and broader antimicrobial and antioxidant properties observed across the Smilax genus. However, the current lack of specific human clinical data for Smilax Utilis Root Extract at defined concentrations and its 'insufficient data' CIR status necessitate further dedicated research to fully establish its precision cosmetic efficacy and safety.

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